Table 1.

Biological markers associated with PF&S operationalized, according to the Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT) project’s definition.

Biological Domain	Biomarkers
Inflammation	CRP, HSP72, IL1β, IL6, IL8, MCP1, MIP1α, MPO, PDGF-BB
Amino acid metabolism	Asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, taurine, threonine
Gut microbiota	Barnesiellaceae, Christensenellaceae, Oscillospira, Ruminococcus

Abbreviations: CRP, C-reactive protein; HSP72, heat shock protein 72; IL, interleukin; MCP1, monocyte chemoattractant protein 1; MIP1α, macrophage inflammatory protein 1α; MPO, myeloperoxidase; PDGF-BB, platelet-derived growth factor-BB.