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. 2020 Aug 5;21(16):5618. doi: 10.3390/ijms21165618

Figure 2.

Figure 2

Models of interaction between the LMV VPg central domain (blue) and lettuce eIF4E (mo10 isoform). (A–C), eIF4E interaction with VPg88–111, VPg88–120 and VPg107–120, respectively. The coordinates of the LMV VPg (LMV-AF199 isolate GenBank: AJ278854.1) and lettuce eIF4E (mo10 isoform, GenBank: AF530162.1) were first derived by homology modeling from the VPg (PDB 6NFW) and eIF4E (pisum sativum, PDB 2WMC), respectively. The binary Complex was modeled by restraint-driven docking (Haddock web server), using a set of amino acids homologous to the ones identified elsewhere [21]. V and E subscripts refer to the residues belonging to VPg and eIF4E, respectively.