NAFLD |
Nonalcoholic fatty liver disease |
NAFL |
Nonalcoholic fatty liver |
NASH |
Nonalcoholic steatohepatitis |
THs |
Thyroid hormones |
HCs |
Hepatic cells |
HCC |
Hepatocellular carcinoma |
HIN |
Hypothyroidism-induced NAFLD |
SCH |
Subclinical hypothyroidism |
IR |
Insulin resistance |
BMI |
Body mass index |
TSH |
Thyroid-stimulating hormone |
fT4 |
Free Thyroxine |
LT4
|
Levothyroxine |
AST |
Aspartate aminotransferase |
ALT |
Alanine aminotransferase |
TG |
Triglyceride |
HOMA-IR |
Homeostatic Model Assessment for Insulin Resistance |
TRs |
Thyroid hormone receptors |
T3 |
3,5,3′-triiodothyronine |
T4 |
3,5,3′,5′-tetraiodothyronine |
rT3 |
Reverse T3 |
TRH |
Thyrotropin-releasing hormone |
RXR |
Retinoid X receptor |
TREs |
Thyroid hormone response elements |
THR-α |
Thyroid hormone receptor α1 |
THR-β |
Thyroid hormone receptor β1 |
D1 |
Deiodinases 1 |
D2 |
Deiodinases 2 |
D3 |
Deiodinases 3 |
T2 |
Diiodothyronine |
TGF-β |
Transforming growth factor-beta |
IL6 |
Interleukin-6 |
FFAs |
Free fatty acids |
DNL |
De novo lipogenesis |
L-FABPs |
Liver fatty acid binding proteins |
SREBP-1c |
Sterol regulatory element-binding transcription factor 1 |
ChREBP |
Carbohydrate- Responsive Element-Binding Protein |
PCSK9 |
Proprotein convertase subtilisin/kexin type 9 |
HMG-CoA |
β-Hydroxy β-methylglutaryl-CoA |
Cyp7A1 |
Cholesterol 7 alpha-hydroxylase |
T2DM |
Type 2 diabetes mellitus |
CKD |
Chronic kidney disease |
MRI |
Magnetic Resonance Imaging |
FLI |
Fatty liver index |
USG |
Ultrasonography |
LS |
Longitudinal study |
CSS |
Cross-sectional study |
CCS |
Case-control study |
WAT |
White adipose tissue |
mRNA |
Messenger RNA |
FAS |
Fatty acid synthase |
ACC |
Acetyl-CoA carboxylase |
VLDL |
Very-low-density lipoprotein |
LDL |
Low-Density Lipoproteins |
HDL |
High-Density Lipoproteins |
FATPs |
Fatty acid transporter proteins |
FAT |
Fatty acid translocase |
cAMP |
Cyclic AMP |
PKA |
Protein kinase A |
PPARα |
Peroxisome proliferator-activated receptor-α |
PPAR δ |
Peroxisome proliferator-activated receptor- δ |
AMPK |
AMP-activated protein kinase |
HMGCR |
3-hydroxy-3-methyl-glutaryl coenzyme A reductase |
CETP |
Cholesteryl ester transfer protein |
LCAT |
Lecithin-cholesterol acyltransferase |
ApoA1 |
Apolipoprotein A1 |
ApoC3 |
Apolipoprotein C3 |
SRB1 |
Scavenger receptor class B member 1 |
SOAT2 |
Sterol O-acyltransferase 2 |
ROS |
Reactive oxygen species |
CAT |
Catalase |
CAMKK2 |
Ca2+–calcium/calmodulin-dependent protein kinase kinase 2 |
FGF-21 |
Fibroblast growth factor-21 |
TBA |
Thyroxine-binding albumin |
TBPA |
Thyroxine-binding prealbumin |
TBG |
Thyroxine-binding globulin |
L-FABP |
Hepatic fatty acid-binding protein |
CMD |
Choline-methionine deficient |
COX-2 |
Cyclooxygenase-2 |
AOX |
Acyl-CoA oxidase |
phosphor-SAPK/JNK |
Phosphor-stress-activated protein kinase/c-Jun NH2-terminal kinase |
phosphor-STAT3 |
Phosphor-signal transducer and activator of transcription 3 |
PGC-1α |
Peroxisome proliferator-activated receptor γ coactivator-1α |
CPT-1 |
Carnitine palmitoyltransferase-1 |
T1AM |
3-iodothyronamine |
STIR1 |
Hepatic nuclear sirtuin 1 |
AKT |
Protein kinase B |
MAPK/ERK |
Mitogen-activated protein kinase/extracellular signal-regulated kinase |
TAAR1 |
Trace amine-associated receptor |
TQ |
Thymoquinone |
NG |
Nigella salvia
|
PTU |
6-propyl-2-thiouracil |
α-SMA |
Alpha-smooth muscle actin |
HSCs |
Hepatic stellate cells |
GC-1 |
Sobetirome |
KB-2115 |
Eprotirome |
MGL-3196 |
Resmetirom |
MRI-PDFF |
MRI-proton density fat fraction |