Figure 1.

Age-related macular degeneration (AMD) is an eye disease affecting the macula, a central region in the retina. Individuals affected by AMD in its advanced stage may experience a profound loss of central vision. (A,B) Color pictures of retina with changes typical for early stages of AMD, typified by the presence of numerous large drusen, more or less confluent, and associated (or not) with retinal pigment epithelium (RPE) abnormalities (arrow). (C,D) Color and autofluorescence (AF) pictures of fundus for retina with changes typical for dry AMD. (C) The advanced form of dry AMD is typified by the presence of central geographic atrophy (GA) showing a sharply demarcated atrophic lesion of the outer retina, resulting from the loss of photoreceptors, RPE, and choriocapillaris (asterisk). (D) GA areas typically appear as dark patches in fundus AF images, and can be clearly delineated (asterisk).