Table 2.

TIMPs polymorphisms associated with AMD.

Gene	Polymorphism	Authors, Year, Reference	Subjects (n)			Association between TIMP Genetic Variants and AMD
			AMD Patients		Control Subjects
			WET AMD	DRY AMD
TIMP-2	g.78925807C>G (rs8179090)	Ortak et al. 2013 [36]	144		172	*
			37	107
		Oszajca et al. 2018 [31]	100	100	100	GC genotype was significantly associated with a protective effect
TIMP-3	g.32688525A>C (rs9621532)	Neale et al. 2010 [24]	979		1079	C allele was associated with lower risk of AMD
		Chen et al. 2010 [125]	10049		7148	A allele was associated with increased risk of AMD
		Fauser et al. 2011 [196]	1201		562	*
		Yu et al. 2011 [195]	2594		4134	C allele seemed to have a protective role from the development of AMD
		Zeng et al. 2012 [198]	136	–	181	*
		Ardeljan et al. 2013 [194]	537		921	C allele seemed to have a protective role from the development wet AMD
			189	348
		Liutkeviciene et al. 2019 [199]	610		306	*
			–	306
	g.32709831T>C (rs5754227)	Fritsche et al. 2016 [28]	16144		17832	C allele was significantly associated within the control group.
	g.32812451C>T (rs713685)	Kaur, Rathi & Chakrabarti 2010 [193]	250		250	C allele was more frequent in AMD patients.
	g.32838192C>G (rs743751)	Kaur, Rathi & Chakrabarti 2010 [193]	250		250	G allele was more frequent in AMD patients.
	g.32833610G>A (rs6518799)	Kaur, Rathi & Chakrabarti 2010 [193]	250		250	*
	g.32709241A>G (rs756481)	Ardeljan et al. 2013 [194]	537		921	*
			189	348
	g.32710961G>T (rs5749498)	Ardeljan et al. 2013 [194]	537		921	*
			189	348
	g.32715261C>T (rs12170368)	Ardeljan et al. 2013 [194]	537		921	*
			189	348
	g.32848327C>T (rs1427385)	Ardeljan et al. 2013 [194]	537		921	*
			189	348

* Statistically association has not been reported.