. 2020 May;16(2):90–97. doi: 10.2174/1573403X15666190725121246

Table 1.

Clinical criteria for cardiac involvement in sarcoidosis.

Heart Rhythm Society (2014)	Japanese Circulation Society (2017)
Histological diagnosis of extra-cardiac sarcoidosis AND ≥ 1 of the following: - Immunosuppressant responsive cardiomyopathy or HB - Unexplained LVEF < 40% - Unexplained sustained VT (spontaneous or induced) - Mobitz type II 2^nd degree HB or 3^rd degree HB - Patchy uptake on PET - Late gadolinium enhancement on CMR - Positive gallium uptake AND - Other causes of cardiac manifestation(s) have been reasonable excluded	- ≥ 2 major criteria OR 1 major criteria and ≥ 2 minor criteria Major Criteria - High-grade AV block - Basal thinning of IV septum or abnormal ventricular wall anatomy - LVEF < 50% - ⁶⁷Ga citrate scintigraphy or abnormal FDG-PET uptake - Late gadolinium enhancement on CMR Minor Criteria - Abnormal ECG findings - SPECT perfusion defects - EMB: interstitial fibrosis or monocyte infiltration over moderate grade

Heart Rhythm Society (2014)

Japanese Circulation Society (2017)

Histological diagnosis of extra-cardiac sarcoidosis AND ≥ 1 of the following:
     - Immunosuppressant responsive cardiomyopathy or HB
     - Unexplained LVEF < 40%
     - Unexplained sustained VT (spontaneous or induced)
     - Mobitz type II 2^nd degree HB or 3^rd degree HB
     - Patchy uptake on PET
     - Late gadolinium enhancement on CMR
     - Positive gallium uptake
AND
     - Other causes of cardiac manifestation(s) have been reasonable excluded

     - ≥ 2 major criteria OR
1 major criteria and ≥ 2 minor criteria
Major Criteria
     - High-grade AV block
     - Basal thinning of IV septum or abnormal ventricular wall anatomy
     - LVEF < 50%
     - ⁶⁷Ga citrate scintigraphy or abnormal FDG-PET uptake
     - Late gadolinium enhancement on CMR
Minor Criteria
     - Abnormal ECG findings
     - SPECT perfusion defects
     - EMB: interstitial fibrosis or monocyte infiltration over moderate grade

Abbreviations: AV: Atrioventricular; CMR: Cardiac Magnetic Resonance Imaging; ECG: Electrocardiogram; EMB: Endomyocardial Biopsy; HB: Heart Block; IV: Interventricular; LVEF: Left Ventricular Ejection Fraction; PET: Positron Emission Tomography; SPECT: Myocardial Perfusion Scintigraphy.