Confocal microscopy analysis of structure of adult and neonatal human and porcine clots formed with 0.5 U/mL Thrombin (A). Average clot fiber alignment (B) and fiber density (C) +/− standard deviation is shown. Alignment: neonatal humans: N=4, adult humans: N=3, neonatal pigs: N=8, adult pigs: N=6. Fiber Density: neonatal humans: N=4, adult humans: N=3, neonatal pigs: N=5, adult pigs: N=3. *p<0.05, **p<0.01.