Table 3.
The associations between four PFASs and hearing impairment (hearing threshold levels >25 dB) (N = 2525).
| Hearing Threshold | |||||||
|---|---|---|---|---|---|---|---|
| PFAS | 500 | 1K | 2K | 3K | 4K | 6K | 8K |
| PFOA | |||||||
| Q1 | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
| Q2 | 0.83 (0.54–1.27) | 1.21 (0.79–1.85) | 1.41 (0.95–2.10) | 1.39 (0.98–1.98) | 1.31 (0.95–1.83) | 1.08 (0.82–1.43) | 1.24 (0.93–1.66) |
| Q3 | 0.89 (0.58–1.35) | 1.22 (0.80–1.85) | 1.26 (0.85–1.87) | 1.38 (0.98–1.96) | 1.12 (0.81–1.56) | 1.08 (0.81–1.44) | 0.87 (0.65–1.18) |
| Q4 | 1.06 (0.70–1.60) | 1.21 (0.80–1.85) | 1.76 (1.20–2.60) | 1.64 (1.16–2.34) | 1.41 (1.01–1.98) | 1.16 (0.86–1.56) | 0.87 (0.64–1.20) |
| P-trend | 0.36 | 0.58 | <0.01 | 0.02 | 0.11 | 0.38 | 0.11 |
| PFOS | |||||||
| Q1 | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
| Q2 | 0.83 (0.53–1.31) | 0.77 (0.49–1.22) | 0.70 (0.46–1.06) | 0.76 (0.53–1.08) | 0.69 (0.50–0.97) | 0.99 (0.75–1.31) | 1.03 (0.77–1.37) |
| Q3 | 0.91 (0.59–1.39) | 1.07 (0.71–1.63) | 1.12 (0.76–1.65) | 1.00 (0.71–1.41) | 0.89 (0.65–1.24) | 1.14 (0.86–1.51) | 0.98 (0.72–1.32) |
| Q4 | 1.41 (0.93–2.17) | 1.16 (0.76–1.77) | 1.60 (1.09–2.37) | 1.20 (0.85–1.71) | 1.02 (0.73–1.44) | 1.11 (0.82–1.50) | 0.99 (0.72–1.35) |
| P-trend | <0.01 | 0.13 | <0.0001 | 0.02 | 0.14 | 0.42 | 0.85 |
| PFNA | |||||||
| Q1 | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
| Q2 | 1.53 (0.99–2.34) | 1.43 (0.93–2.19) | 1.61 (1.09–2.39) | 1.12 (0.80–1.58) | 1.28 (0.93–1.77) | 1.09 (0.83–1.44) | 1.35 (1.01–1.82) |
| Q3 | 1.23 (0.81–1.90) | 1.36 (0.90–2.07) | 1.29 (0.87–1.90) | 0.98 (0.70–1.37) | 1.12 (0.81–1.55) | 1.03 (0.78–1.37) | 1.49 (1.10–2.00) |
| Q4 | 1.37 (0.90–2.10) | 1.39 (0.91–2.12) | 1.68 (1.14–2.46) | 1.52 (1.08–2.13) | 1.53 (1.10–2.14) | 1.30 (0.97–1.75) | 1.59 (1.16–2.17) |
| P-trend | 0.45 | 0.33 | 0.05 | <0.01 | 0.02 | 0.09 | <0.01 |
| PFHxS | |||||||
| Q1 | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
| Q2 | 0.79 (0.52–1.21) | 1.08 (0.72–1.65) | 1.13 (0.76–1.68) | 1.30 (0.91–1.85) | 0.89 (0.63–1.24) | 0.95 (0.72–1.27) | 1.06 (0.78–1.42) |
| Q3 | 0.89 (0.59–1.34) | 0.96 (0.63–1.44) | 1.21 (0.83–1.77) | 1.29 (0.91–1.82) | 0.87 (0.62–1.21) | 1.01 (0.76–1.35) | 1.11 (0.82–1.50) |
| Q4 | 1.26 (0.85–1.87) | 1.44 (0.97–2.15) | 1.73 (1.19–2.52) | 1.44 (1.01–2.05) | 0.93 (0.66–1.31) | 0.94 (0.70–1.28) | 0.84 (0.61–1.15) |
| P-trend | 0.04 | 0.03 | <0.01 | 0.10 | 0.96 | 0.74 | 0.14 |
Data were presented as odds ratios and 95% confidence interval. Models were all adjusted for age, sex, body mass index, education, ethnicity group, family income, and sample weights.