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. 2020 Aug 31;21:604. doi: 10.1186/s12864-020-06981-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Heme treatment reduces ZnMP uptake and alters gene expression in Aedes aegypti female midguts. Ae. aegypti female midguts were incubated in 0 μM or 10 μM hemin chloride for 35 h. a Background corrected ZnMP fluorescence measurements of each dissected midgut. The middle horizontal line on each treatment group represents the mean and the lines above and below represent ±1 SD. Statistical significance shown by the labels a&b. b. Background corrected pHrodo^TM Green Dextran fluorescence of dissected midguts. Heme deficient and exposed midgut fluorescence not significantly distinct (p-value = 0.6316) c Log2 fold change (LogFC) vs Log10 counts per million (LogCPM) graph of genes found differentially expressed. Genes with an adjusted p-value corrected for multiple testing of < 0.00001 (false discovery rate: FDR) are shown in red. d Volcano plot of genes found differentially expressed in analysis