Table 1.
Effects of 1,25-dihydroxyvitamin D3 exposure on gene expression in PD
| Gene name | Gene location | Involvement in brain function | Expression change |
|---|---|---|---|
| C-Ret [115] | 10q11.2 | Neuroprotective effects and antioxidation | Up |
| GDNF [115] | 5p13 | Neuroprotective effects and antioxidation; dopaminergic neurotransmission | Up |
| Nurr1 [116, 117] | 2q22–23 | DA neuronal differentiation and maturation | Up |
| p57kip2 [116, 117] | 11p15.5 | DA neuronal differentiation and maturation | Up |
| SLC30A10 [118] | 2q32.3 | Maintenance of homeostasis of calcium, zinc, iron and manganese | Up |
| SLC39A2 [118] | 14q11.2 | Maintenance of homeostasis of calcium, zinc, iron and manganese | Down |
| TH [119] | 11p15 | Dopaminergic neurotransmission | Up |
C-Ret proto-oncogene tyrosine-protein kinase receptor Ret, GDNF glial cell-derived neurotrophic factor, TH tyrosine hydroxylase