Effects of PADI2 knockout on inflammatory cytokines expression and secretion. (A) The mRNA expression levels of IL-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) in the U937 cells, the differentiated macrophages, and the macrophages stimulated with LPS in the PADI2 knockout group compared with those in the controls. (B) The cytokines secretion levels of IL-1β, IL-6, and TNF-α in the U937 cells, the differentiated macrophages, and the macrophages stimulated with LPS transfected in the PADI2 knockout group compared with those in the control group. ☆
p < 0.05 compared with the U937 cells; * p < 0.05 compared with the differentiated macrophages.