Table 3.

miRNAs associated with structural proteins of corneocytes and cornified envelopes or epidermal barrier function.

miRNA	Target Molecule	Related Skin Disease	Action Mechanism of miRNA	Reference
miR-339-5p ↓	DLX5		Increased involucrin expression through Wnt/β-catenin signaling pathway activation	[91]
miR-107 ↓	Dicer		Increased filaggrin and loricrin expression	[92]
miR-203 (C/EBPα/miR-203 pathway) ↓	ΔNp63α	HPV8 infection	Downregulation of involucrin	[66]
miR-143 ↓	IL-13Rα1	Atopic dermatitis	Reduced filaggrin/ involucrin /loricrin expression through Th2-derived IL-13 activity stimulation	[12,93,94]
Let-7a-5p ↓	RRM2, CCR7		Barrier abnormalities	[95]
miR-26a-5p ↓	HAS3, DEPDC1B, DEPDC1, NAMPT, DENND1B, ADAM19			[95]
miR-10a-5p ↑	HAS3			[12]
miR-29b ↑	BCL2L2		Barrier abnormalities with Increased IFN-γ-induced keratinocyte apoptosis	[12]
miR-6731-5p ↓	S100A7		IL-22-stimulated keratinocyte proliferation	[96]
miR-146a ↑	EGFR		Terminal differentiation and proliferation inhibition in keratinocytes	[62]
miR-30a-3p ↓		Familial acne inversa	Abnormal keratinocyte differentiation by accelerated EGFR degradation	[97]

↑: upregulation, ↓: downregulation.