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. 2020 Aug 7;21(16):5676. doi: 10.3390/ijms21165676

Figure 4.

Figure 4

Genetic deletion of EAAC1 reduces adult hippocampal neurogenesis after ischemia. (A) The schematic drawing shows that cell proliferation and neuronal differentiation are reduced in the EAAC1−/− mice after ischemia, which means that EAAC1 gene deletion influences the entire process of adult neurogenesis. (B) Representative images showing the bromodeoxyuridine (BrdU)- and DCX-positive cells in the hippocampal DG from WT and EAAC1−/− mice (3–5 months old; weight 25–35 g) at 7 days after ischemia or sham surgery. Scale bar = 50 µm. (C) Double-label confocal micrographs of BrdU (green) and neuronal nuclei (NeuN) (red) in the hippocampal DG from WT and EAAC1−/− mice (3–5 months old; weight 25–35 g) at 30 days after ischemia or sham surgery. Scale bar = 20 µm.