Table 3.
OSA severity (AHI) and risk of incident CKD (stage ≥3): The ARIC-SHHS study (n=1525)
| AHI Category | <5 | 5–14.9 | 15–29 | ≥30 | P Value Trend |
|---|---|---|---|---|---|
| Incident CKD, n | 222 | 135 | 60 | 44 | |
| Model 1 | 1 (reference) | 0.92 (0.74 to 1.15) | 0.93 (0.70 to 1.25) | 1.50 (1.08 to 2.08) | 0.02 |
| Model 2 | 1 (reference) | 0.96 (0.77 to 1.20) | 0.93 (0.69 to 1.25) | 1.51 (1.08 to 2.10) | 0.02 |
| Model 3 | 1 (reference) | 0.89 (0.71 to 1.10) | 0.78 (0.58 to 1.05) | 1.07 (0.75 to 1.52) | 0.98 |
| Model 4 | 1 (reference) | 0.82 (0.65 to 1.03) | 0.79 (0.59 to 1.07) | 1.04 (0.73 to 1.48) | 0.89 |
Model 1: Adjusted for age, sex, center, and education. Model 2: Adjusted for Model 1 + smoking, alcohol consumption, and physical activity. Model 3: Adjusted for Model 2 + BMI. Model 4: Adjusted for Model 3 + hsCRP, prevalent diabetes, systolic BP, diastolic BP, antihypertensive medications, and prevalent CHD.