Table 4.

OSA severity (Hypoxic Burden) and risk of incident CKD (stage ≥3): The ARIC-SHHS study (n=1525)

Hypoxic Burden Category	<1%	1 to <5%	≥5%	P Value Trend
Incident CKD, n	301	87	73
Model 1	1 (reference)	1.20 (0.94 to 1.53)	1.30 (1.01 to 1.69)	0.19
Model 2	1 (reference)	1.22 (0.95 to 1.55)	1.29 (0.99 to 1.68)	0.24
Model 3	1 (reference)	1.06 (0.83 to 1.37)	1.00 (0.75 to 1.32)	0.67
Model 4	1 (reference)	1.06 (0.82 to 1.36)	0.99 (0.74 to 1.31)	0.74

Model 1: Adjusted for age, sex, center, and education. Model 2: Adjusted for Model 1 + smoking, alcohol consumption, and physical activity. Model 3: Adjusted for Model 2 + BMI. Model 4: Adjusted for Model 3 + hsCRP, prevalent diabetes, systolic BP, diastolic BP, antihypertensive medications, and prevalent CHD.