Table 5.

PSG-assessed arousal index and risk of incident CKD (stage ≥3): The ARIC-SHHS study

Arousal Index Quartiles	1	2	3	4	P Value Trend
Range	[3–12.4]	[12.5–16.8]	[16.9–23.7]	[23.8–90.8]
Average no. of arousals per hour	9.35	14.61	19.92	32.49
Incident CKD, n	107	108	108	127
Model 1	1 (reference)	0.96 (0.73 to 1.25)	0.92 (0.70 to 1.21)	1.12 (0.86 to 1.46)	0.18
Model 2	1 (reference)	0.97 (0.73 to 1.26)	0.91 (0.70 to 1.20)	1.12 (0.86 to 1.47)	0.17
Model 3	1 (reference)	0.97 (0.74 to 1.27)	0.87 (0.66 to 1.14)	1.04 (0.80 to 1.36)	0.54
Model 4	1 (reference)	0.99 (0.75 to 1.30)	0.85 (0.64 to 1.11)	1.08 (0.82 to 1.41)	0.52

Model 1: Adjusted for age, sex, center, and education. Model 2: Adjusted for Model 1 + smoking, alcohol consumption, and physical activity. Model 3: Adjusted for Model 2 + BMI. Model 4: Adjusted for Model 3 + hsCRP, prevalent diabetes, systolic BP, diastolic BP, antihypertensive medications, and prevalent CHD.