Table 1.
ECM proteins with differential abundance between cFSGS and FSGS-NOS
| Protein Name | Gene Name | Log2 Fold Change | P Value | q Value | Category | Division |
|---|---|---|---|---|---|---|
| Proteins with greater abundance in cFSGS | ||||||
| Annexin A3 | ANXA3 | 3.04 | 1.96e−07 | 1.69e−06 | ECM-affiliated proteins | Matrisome associated |
| Apolipoprotein C3 | APOC3 | >5.0 | 1.92e−11 | 5.65e−10 | ECM-affiliated proteins | Matrisome associated |
| Azurocidin | AZU1 | >5.0 | 3.81e−08 | 3.92e−07 | ECM regulators | Matrisome associated |
| Complement C1q A chain | C1QA | >5.0 | 4.55e−05 | 2.81e−04 | ECM-affiliated proteins | Matrisome associated |
| Complement C1q B chain | C1QB | >5.0 | 7.11e−09 | 8.09e−08 | ECM-affiliated proteins | Matrisome associated |
| Complement C1q C chain | C1QC | 3.20 | 7.58e−04 | 3.09e−03 | ECM-affiliated proteins | Matrisome associated |
| Collagen α-1 (XII) chain | COL12A1 | 2.31 | 0.0443 | 0.1115 | Collagens | Structural matrisome |
| Collagen α-1 (XXI) chain | COL21A1 | 2.91 | 4.04e−03 | 0.017 | Collagens | Structural matrisome |
| Collagen α-1 (VII) chain | COL7A1 | 3.30 | 0.0462 | 0.1149 | Collagens | Basement membrane |
| Cysteine-rich transmembrane BMP regulator 1 | CRIM1 | 4.58 | 8.05e−12 | 3.23e−10 | ECM glycoproteins | Structural matrisome |
| Chondroitin sulfate proteoglycan 4 | CSPG4 | 1.13 | 6.56e−04 | 2.74e−03 | ECM-affiliated proteins | Matrisome associated |
| Cathepsin B | CTSB | 3.09 | 0.3219 | 0.4759 | ECM regulators | Matrisome associated |
| Cathepsin C | CTSC | 3.61 | 4.21e−07 | 3.41e−06 | ECM regulators | Matrisome associated |
| Cathepsin G | CTSG | 5.67 | 1.52e−07 | 1.36e−06 | ECM regulators | Matrisome associated |
| Cathepsin L | CTSL | 4.96 | 5.06e−08 | ECM regulators | Matrisome associated | |
| ECM protein 1 | ECM1 | 4.10 | 4.31e−05 | 2.24e−04 | ECM glycoproteins | Structural matrisome |
| Neutrophil elastase | ELANE | 4.55 | 4.61e−09 | 5.71e−08 | ECM regulators | Matrisome associated |
| Coagulation factor XII | F12 | 4.15 | 4.21e−05 | 2.21e−04 | ECM regulators | Matrisome associated |
| Fibrillin 2 | FBN2 | 2.26 | 2.09e−07 | 1.76e−06 | ECM glycoproteins | Structural matrisome |
| Fibrinogen-like protein 1 | FGL1 | 4.25 | 1.69e−09 | 3.35e−08 | ECM glycoproteins | Structural matrisome |
| Hydroxysteroid 17-β dehydrogenase 12 | HSD17B12 | 3.09 | 1.12e−04 | 6.69e−04 | ECM-affiliated proteins | Matrisome associated |
| Insulin-like growth factor binding protein acid-labile subunit | IGFALS | >5.0 | 0.1133 | 0.2317 | ECM glycoproteins | Structural matrisome |
| Insulin-like growth factor binding protein 7 | IGFBP7 | 2.77 | 2.71e−09 | 3.64e−08 | ECM glycoproteins | Structural matrisome |
| Inter-α-trypsin inhibitor heavy chain 5 | ITIH5 | 2.85 | 1.09e−03 | 4.25e−03 | ECM regulators | Matrisome associated |
| Kininogen 1 | KNG1 | 1.63 | 5.74e−05 | 2.91e−04 | ECM regulators | Matrisome associated |
| Laminin subunit α 3 | LAMA3 | 2.57 | 2.42e−03 | 0.011 | ECM glycoproteins | Basement membrane |
| Laminin subunit β 1 | LAMB1 | 1.85 | 3.78e−03 | 0.013 | ECM glycoproteins | Basement membrane |
| Galectin 3 | LGALS3 | 2.53 | 4.76e−09 | 5.74e−08 | ECM-affiliated proteins | Matrisome associated |
| Galectin 7 | LGALS7 | 3.67 | 2.62e−06 | 1.72e−05 | ECM-affiliated proteins | Matrisome associated |
| Lectin, mannose binding 1 | LMAN1 | 2.26 | 3.98e−08 | 4.00e−07 | ECM-affiliated proteins | Matrisome associated |
| Matrix metalloproteinase 9 | MMP9 | >5.0 | 0.0978 | 0.2216 | ECM regulators | Matrisome associated |
| Myeloperoxidase | MPO | 3.25 | 1.77e−03 | 6.53e−03 | ECM regulators | Matrisome associated |
| Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 | PLOD3 | 2.54 | 0.0115 | 0.0353 | ECM regulators | Matrisome associated |
| Proteoglycan 3 | PRG3 | >5.0 | 9.77e−12 | 3.39e−10 | Proteoglycans | Structural matrisome |
| Serine protease 23 | PRSS23 | 4.22 | 6.04e−07 | 4.58e−06 | ECM regulators | Matrisome associated |
| S100 calcium binding protein A8 | S100A8 | 2.18 | 0.0492 | 0.121 | Secreted factors | Matrisome associated |
| S100 calcium binding protein A9 | S100A9 | >5.0 | 2.31e−07 | 1.93e−06 | Secreted factors | Matrisome associated |
| Serpin family D member 1 | SERPIND1 | 4.12 | 3.88e−08 | 3.96e−07 | ECM regulators | Matrisome associated |
| Transthyretin | TTR | 2.88 | 2.18e−04 | 1.20e−03 | ECM regulators | Matrisome associated |
| Serpin family F member 2 | SERPINF2 | 4.18 | 6.47e−09 | 7.65e−08 | ECM regulators | Matrisome associated |
| Uromodulin | UMOD | 4.66 | 5.75e−12 | 2.48e−10 | ECM glycoproteins | Structural matrisome |
| Proteins with greater abundance in FSGS-NOS | ||||||
| Biglycan | BGN | 2.98 | 2.12e−09 | 2.97e−08 | Proteoglycans | Structural matrisome |
| Collagen α-1 (I) chain | COL1A1 | 3.71 | 4.08e−03 | 0.0139 | Collagens | Structural matrisome |
| Collagen α-2 (I) chain | COL1A2 | 2.66 | 4.24e−03 | 0.0143 | Collagens | Structural matrisome |
| Collagen α-1 (XV) chain | COL15A1 | 3.28 | 0.2057 | 0.3533 | Collagens | Basement membrane |
| Collagen α-1 (III) chain | COL3A1 | 1.70 | 0.4772 | 0.6235 | Collagens | Basement membrane |
| Cystatin-C | CST3 | 4.37 | 1.05e−08 | 1.57e−07 | ECM regulators | Matrisome associated |
| Fibulin 5 | FBLN5 | 0.76 | 0.0327 | 0.0859 | ECM glycoproteins | Structural matrisome |
| Filaggrin family member 2 | FLG2 | 1.22 | 0.0161 | 0.0475 | Secreted factors | Matrisome associated |
| HtrA serine peptidase 1 | HTRA1 | 4.10 | 3.58e−06 | 2.29e−05 | ECM regulators | Matrisome associated |
| Inhibin β E chain | INHBE | 4.32 | 6.17e−11 | 2.22e−09 | Secreted factors | Matrisome associated |
| Inter-α-trypsin inhibitor heavy chain H4 | ITIH4 | 1.68 | 3.03e−03 | 0.0131 | ECM regulators | Matrisome associated |
| Lipoprotein(a) | LPA | 1.86 | 1.81e−04 | 8.30e−04 | ECM regulators | Matrisome associated |
| Peroxidasin | PXDN | 3.07 | 5.59e−03 | 0.0227 | ECM glycoproteins | Structural matrisome |
| Serum amyloid A1 | SAA1 | 5.65 | 1.01e−05 | 5.97e−05 | ECM regulators | Matrisome associated |
| Serpin family B member 12 | SERPINB12 | 2.18 | 1.22e−03 | 5.90e−03 | ECM regulators | Matrisome associated |
| Serpin family G member 1 | SERPING1 | 3.34 | 0.8085 | 0.8878 | ECM regulators | Matrisome associated |
| von Willebrand factor | VWF | 1.92 | 0.0118 | 0.0362 | ECM glycoproteins | Structural matrisome |