Table 2.
Transcript analysis for ECM proteins with differential abundance between cFSGS and FSGS-NOS
| Protein Name | Gene Name | Log2 Fold Change (FSGS to NC) | q Value | Log2 Fold Change (cFSGS to FSGS- NOS) | P Value |
|---|---|---|---|---|---|
| Proteins with greater abundance in cFSGS | |||||
| Annexin A3 | ANXA3 | 1.13 | 0.070 | 0.80 | 0.068 |
| Apolipoprotein C3 | APOC3 | 0.61 | 0.030 | −0.72 | 0.091 |
| Azurocidin | AZU1 | 1.03 | 0.380 | 0.122 | 0.852 |
| Complement C1q A chain | C1QA | ND | 0.30 | 0.473 | |
| Complement C1q B chain | C1QB | ND | 0.28 | 0.556 | |
| Complement C1q C chain | C1QC | ND | 0.40 | 0.089 | |
| Collagen α-1 (XII) chain | COL12A1 | ND | 0.40 | 0.034 | |
| Collagen α-1 (XXI) chain | COL21A1 | ND | −0.19 | 0.527 | |
| Collagen α-1(VII) chain | COL7A1 | 1.28 | 0.001 | 0.07 | 0.505 |
| Cysteine-rich transmembrane BMP regulator 1 | CRIM1 | 0.86 | 0.001 | −0.10 | 0.524 |
| Chondroitin sulfate proteoglycan 4 | CSPG4 | 1.07 | 0.080 | 0.00 | 1.000 |
| Cathepsin B | CTSB | ND | 0.54 | 0.043 | |
| Cathepsin C | CTSC | 1.5 | 0.001 | 0.54 | 0.252 |
| Cathepsin G | CTSG | 0.96 | 0.190 | 0.29 | 0.722 |
| Cathepsin L | CTSL | ND | −0.20 | 0.166 | |
| ECM protein 1 | ECM1 | 2.67 | 0.001 | −0.10 | 0.834 |
| Neutrophil elastase | ELANE | ND | 0.17 | 0.577 | |
| Coagulation factor XI | F12 | 0.94 | 0.090 | −0.06 | 0.858 |
| Fibrillin 2 | FBN2 | 1.35 | 0.001 | 0.26 | 0.373 |
| Fibrinogen-like protein 1 | FGL1 | ND | ND | ||
| Hydroxysteroid 17-β dehydrogenase 12 | HSD17B12 | ND | 0.40 | 0.047 | |
| Insulin-like growth factor binding protein acid labile | IGFALS | 0.92 | 0.030 | 0.07 | 0.704 |
| Insulin-like growth factor binding protein 7 | IGFBP7 | 1.06 | 0.070 | −0.20 | 0.483 |
| Inter-α-trypsin inhibitor heavy chain 5 | ITIH5 | ND | −0.29 | 0.363 | |
| Kininogen 1 | KNG1 | 0.71 | 0.001 | 0.27 | 0.614 |
| Laminin subunit α 3 | LAMA3 | ND | 0.31 | 0.162 | |
| Laminin subunit β 1 | LAMB1 | 1.11 | 0.160 | 0.13 | 0.447 |
| Galectin 3 | LGALS3 | ND | 0.52 | 0.025 | |
| Galectin 7 | LGALS7 | ND | −0.39 | 0.924 | |
| Lectin, mannose binding 1 | LMAN1 | 0.88 | 0.010 | 0.00 | 1.000 |
| Matrix metalloproteinase 9 | MMP9 | ND | −0.10 | 0.799 | |
| Myeloperoxidase | MPO | ND | −0.08 | 0.880 | |
| Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 | PLOD3 | 1.13 | 0.001 | 0.84 | 0.090 |
| Proteoglycan 3 | PRG3 | 0.95 | 0.080 | ND | |
| Serine protease 23 | PRSS23 | 1.48 | 0.001 | 1.15 | 0.050 |
| S100 calcium binding protein | S100A8 | 0.91 | 0.320 | −0.35 | 0.412 |
| S100 calcium binding protein | S100A9 | 0.88 | 0.290 | −0.31 | 0.344 |
| Serpin family D member 1 | SERPIND1 | 1.13 | 0.060 | −0.35 | 0.224 |
| Transthyretin | TTR | ND | −0.25 | 0.619 | |
| Serpin family F member 2 | SERPINF2 | ND | 0.00 | 1.000 | |
| Uromodulin | UMOD | 0.69 | 0.001 | −0.50 | 0.510 |
| Proteins with greater abundance in FSGS-NOS | |||||
| Biglycan | BGN | 1.2 | 0.020 | −0.02 | 0.560 |
| Collagen α-1 (I) chain | COL1A1 | 1.49 | 0.001 | 1.80 | 0.004 |
| Collagen α-2 (I) chain | COL1A2 | 2.82 | 0.001 | 0.70 | 0.160 |
| Collagen α-1 (XV) chain | COL15A1 | 1.94 | 0.001 | 0.09 | 0.824 |
| Collagen α-1 (III) chain | COL3A1 | ND | 0.20 | 0.640 | |
| Cystatin-C | CST3 | ND | 0.30 | 0.409 | |
| Fibulin 5 | FBLN5 | 0.95 | 0.230 | −0.30 | 0.389 |
| Filaggrin family member 2 | FLG2 | ND | 0.00 | 1.000 | |
| HtrA serine peptidase 1 | HTRA1 | 0.97 | 0.280 | −0.75 | 0.236 |
| Inhibin β E chain | INHBE | ND | 0.05 | 0.990 | |
| Inter-α-trypsin inhibitor heavy chain H4 | ITIH4 | ND | −0.53 | 0.642 | |
| Lipoprotein(a) | LPA | 0.93 | 0.070 | −0.36 | 0.465 |
| Peroxidasin | PXDN | ND | 1.00 | 0.015 | |
| Serum amyloid A1 | SAA1 | ND | −0.14 | 0.827 | |
| Serpin family B member 12 | SERPINB12 | ND | ND | ||
| Serpin family G member 1 | SERPING1 | 1.05 | 0.160 | 0.5 | 0.044 |
| von Willebrand factor | VWF | 1.00 | 0.280 | 0.10 | 0.680 |
ND, not determined.