Figure 1.
EPCR deficiency has no effect on dNP. (A and B) Dot plot summarizing (A) urine albumin levels (albumin-creatinine ratio) or (B) blood glucose levels in control and diabetic wild-type (WT) and EPCR-deficient (EPCRδ/δ) mice. Albuminuria and blood glucose levels are not different between control or diabetic EPCRδ/δ mice as compared with control or diabetic wild-type mice, respectively. (C) Representative images of glomeruli (left; PAS staining of paraffin-fixed sections; scale bar, 5 μm) and dot plot summarizing data for the FMA (right). Data shown as dot plots represent mean±SEM of at least six mice per group. ***P<0.005. (A and B) ANOVA with Tukey-adjusted post hoc comparison; diabetic mice (DM) were compared with corresponding (WT or EPCRδ/δ) nondiabetic control mice and diabetic WT mice were compared with diabetic EPCRδ/δ mice. C, control; DM, mice with persistent hyperglycemia after STZ injection.