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Bioaction of MaR1, RvD1, and NPD1.
| SPMs | Receptor | Bioaction in AD | Reference |
|---|---|---|---|
| MaR1 | LGR6 | Promote microglial phagocytosis of Aβ Promote tissue regeneration Analgesic effect |
[50,111,113] |
| RvD1 | ALX/FPR2 & GPR32 | Enhance tissue remodeling in microglia Promote macrophage phagocytosis of Aβ |
[117,118,119] |
| NPD1 | GPR37 | Influence cell survival, neuroinflammatory signaling and transcription Suppress the production of APP |
[51,120,121] |
