Figure 1.

Perfusion of the hearts of young mice with linagliptin at human C_max equivalent enhances contractile recovery after ischemia reperfusion injury. Percentage recovery of left ventricular developed pressure 40 min after reperfusion (%LVDP R40) in the hearts of male (purple circles) and female (red circles) C57BL/6 mice aged 7–8 weeks perfused with vehicle (Krebs Henseleit buffer, KHB; n = 19) or KHB supplemented with 9 nmol/L linagliptin (n = 23), 817 nmol/L sitagliptin (n = 23), 110 ng/mL alogliptin (n = 22) or 24 ng/mL saxagliptin (n = 20). Values are mean ± S.D.. *p < 0.05, **p < 0.01 by one-way ANOVA followed by Fisher least significant difference post hoc test.