Table 1.
Effect of different DPP-4 inhibitors, administered at human Cmax equivalent, on the ex vivo function of hearts of non-diabetic young mice at baseline and 40 min after ischemia perfusion (R40).
| LVDP (cmH2O) | dP/dtmax (cmH2O × ms−1) | dP/dtmin (cmH2O × ms−1) | Heart Rate (bpm) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Baseline | R40 | Baseline | R40 | Baseline | R40 | Baseline | R40 | |
| Vehicle | 19 | 94 ± 32 | 21 ± 16 | 3493 ± 1527 | 1268 ± 904 | −2821 ± 979 | −1127 ± 746 | 278 ± 86 | 348 ± 89 |
| Linagliptin | 23 | 95 ± 35 | 42 ± 32 a | 3957 ± 1957 | 2426 ± 2025 | −2762 ± 1080 | −1782 ± 1207 | 306 ± 77 | 377 ± 90 |
| Sitagliptin | 23 | 84 ± 29 | 21 ± 16 b | 4058 ± 2317 | 1667 ± 1188 | −2706 ± 1063 | −1335 ± 840 | 277 ± 95 | 340 ± 89 |
| Alogliptin | 22 | 88 ± 43 | 20 ± 18 b | 4134 ± 2722 | 1492 ± 1077 | −2930 ± 1486 | −1289 ± 908 | 294 ± 97 | 331 ± 87 |
| Saxagliptin | 20 | 90 ± 36 | 23 ± 18 c | 3898 ± 2522 | 1765 ± 1632 | −2765 ± 1158 | −1297 ± 894 | 300 ± 109 | 332 ± 121 |
Values are mean ± S.D.. a p < 0.01 vs. vehicle, b p < 0.001 vs. linagliptin, c p < 0.01 vs. linagliptin by one-way ANOVA followed by Fisher least significant difference post hoc test. bpm = beats per minute.