Figure 4.

Overview of proteins involved in dysfunctional pathways in chronic mitochondrial complex III inhibition. Dysfunctional fatty acid metabolism, TCA cycle, and ETC can significantly decrease mitochondrial energy production. Pathways of amino acid metabolism converge closely with fatty acid metabolism to further decrease mitochondrial metabolism. Increased protein import and decreased toxic clearance of damaged proteins can ultimately lead to mitochondrial dysfunction, triggering a glycolytic switch.