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Expression Changes in MMP-2, MMP-9, TIMP1, DDR2 and (p)SMAD2/3/total SMAD2/3 in B6 and EphA2-R-M Mouse Hearts. MMP-9, MMP-2 and TIMP-1 expression in ephrinA1-Fc-treated +/-TGF-β primary cardiac fibroblasts are modulated in a dose-dependent manner (n = 3/group; significance: * vs. control, † vs. 0.1 µM EA1, ‡ vs. TGF-β). Western blots of DDR2 and (p)SMAD2/3/totalSMAD2/3 show dose-dependent changes in response to ephrinA1-Fc-treatment +/-TGF-β (NS).
