Editor
Since the first case of SARS-CoV-2 was confirmed, lives were altered in many ways, elective surgery was discontinued and outpatient clinics were cancelled or altered to phone consultations1–5. Anecdotal evidence suggests a reduction of acute surgical admissions, however there is paucity of studies looking into the causative factors. It was anticipated by some that as a result of the ‘lock-down’ patients would deteriorate at home without access to hospital treatment, leading to late presentations.
We performed a multicentre study at sixteen hospitals aiming to evaluate the patients with acute surgical inflammatory processes (ASIP) (appendicitis, cholecystitis, diverticulitis and perianal abscesses) during the COVID-19 outbreak and compare it with the same timeframe in 2019. Consecutive patients from March 14th 2020 (date of the declaration of the state of alarm by Spanish Government) until the May 2th 2020 (beginning of the gradual de-escalation plan) were included. In total, 521 patients were treated for ASIP in 2020 (cases) and 822 in 2019 (controls). This represents a 36·6% (appendicitis -33·4%, cholecystitis -22·9%, diverticulitis -60% anal perianal abscesses -41%) reduction. The higher reduction was observed in mild and moderate cases (-49·3% and -19·5%, respectively), with a similar number of severe cases (86 vs. 97; variation -11·3%). The percentage of patients treated surgically was lower in 2020 (380 [72·9%] vs. 658 [80%]; p = 0·002). Although the cases group had more complications (117 [22·5%] vs. 101 [12·3%]; p < 0·001) the number of severe complications (grade 3 or higher) was similar (37 [7·1%] vs. 45 [5·5%]; p = 0·225).
Thirty-seven out of three hundred forty-five patients tested for COVID-19 (66·2%) were COVID-19 positive (10·7% of tested and 7·5% of total). Patients positive for COVID test were more commonly classified as “severe” at diagnosis but without reaching statistical significance (11 [29·7%] vs. 47 [15·4%]; p = 0·072). These patients were treated surgically less frequently (17 [45·9%] vs. 219 [71·1%]; p = 0·002). Although patients diagnosed with COVID-19 experienced a higher number of severe complications (7 [18·9%] vs. 22 [7·1%]; p = 0·024), a logistic regression analysis showed this to be associated with CCI and severity at presentation instead of COVID-19 status instead (Table 1). Mortality was similar for COVID-19 positive and negative patients (2 [5·4%] vs. 3 [1%]; p = 0·091). Patients waited longer before presenting to hospital after the onset of symptoms (> 3 days: 252 [48·4%] vs. 276 [33·7%], p < 0·001; > 7 days: 79 [15·2%] vs. 68 [8·3%], p < 0·001) and were operated on less during the pandemic (380 [72·9%] vs. 658 [80%]; p = 0·002).
Table 1.
Logistic regression analysis
| Variable | OR | 95% CI | p-value |
|---|---|---|---|
| Severe complications | |||
| CCI | 1·193 | 1·031-1·380 | 0·018 |
| Non-surgical treatment | Ref | ||
| Surgical treatment | 2·081 | 0·765-5·659 | 0·151 |
| COVID negative | Ref | ||
| COVID positive | 2·628 | 0·961-7·189 | 0·060 |
| Severity at diagnosis - Mild | Ref | ||
| Moderate | 2·574 | 0·893-7·421 | 0·080 |
| Severe | 5·091 | 1·757-14·753 | 0·003 |
Our conclusion is that, whilst the COVID-19 outbreak led to delayed presentations and selected more severe ASIP cases, the positive COVID-19 status itself did not have a direct impact on either morbidity or mortality. Based on these results, we recommend that treatment of ASIP cases to retrovert to that of pre-COVID era (i.e. surgery > conservative management).
Contributor Information
H Guadalajara, Email: hector.guadalajara@uam.es.
PIACO Collaboration Group:
J M Fernández-Cebrián, A Blazquez Martin, J M Jover, M A Iparraguirre, D Acín-Gándara, E Perea-del-Pozo, S Dios-Barbeito, E Martin-Antona, M Durán-Poveda, B Peinado Iribar, A Moreno Elola-Olaso, I Pascual Migueláñez, S Gortázar de las Casas, G Paseiro Crespo, R Pardo, D Fernández Luengas, A Garcia Chiloeches, A Puerta, R Maqueda González, M Gutiérrez Samaniego, L Colao García, J Serrano González, S Núñez O'Sullivan, C Rodriguez Haro, M A Vaquero, A Picardo Nieto, C Vera-Mansilla, M Pérez-González, S Soto Schütte, A Gutiérrez Calvo, A Sanchez Argüeso, S Hernández-Villafranca, S Qian Zhang, M Gorosabel, J Mínguez García, L Casalduero García, M Florez Gamarra, J M Arguello Andres, B Tallon Iglesias, V García Gutierrez, F Pereira Perez, D Aparicio-Sanchez, V Durán-Muñoz-Cruzado, F Pareja-Ciuró, O Cano-Valderrama, R Avellana, A J Torres-Garcia, L Zarain Obrador, D Fernandez Luengas, M A Garcia Ureña, C Toribio Vazquez, and M L Fuenmayor-Valera
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