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. 2020 Aug 13;21(16):5800. doi: 10.3390/ijms21165800

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Example of gene overexpression. Here using RNA-sequencing we examined overexpression of CCDN1 in cell lines derived from various lymphoma subgroups: anaplastic large cell lymphoma (ALCL); Burkitt lymphoma/B-acute lymphoblastic leukemia (B-ALL); diffuse large B-cell lymphoma (DLBCL) with its ABC (activated B-cell) and GCB (germinal center B-cell) variants; MCL; and MM/PCL. Note that 7/8 CCND1-positive cell lines carry aberrations affecting 11q13, the locus of the aberrantly expressed gene (five MCL and two MM/PCL cell lines).