Table 1.

Advantages and Key Features of Leukemia–Lymphoma Cell Lines.

Major Advantages

Unlimited supply of cell material

Worldwide availability of identical cell material

Infinite storability in liquid nitrogen and recoverability

Absence of contaminating normal material

Key Features

Monoclonal origin

Differentiation arrest at a discrete maturation stage

Sustained proliferation in culture

Stability of most features in long-term cultures

Specific genetic alterations

Retention of tumor gene expression patterns

Modified from Reference [11].