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Effects of compounds 3, 4, 6, 9 at the dose of 30 mg/kg, ip, and morphine (5 mg/kg) on response latency in the hot plate test in mice. Data are presented as mean ± SEM and were analyzed by one-way analysis of variance, followed by Dunnett’s post hoc test or t-test. Significant difference compared to the vehicle-treated group—* p < 0.05, *** p < 0.001; n = 8.
