Table 1.
1H-NMR signals of the 1,3,4-thiadiazole derivatives 1–3.
| Thiadiazole Serivative | 1H-NMR Signals: δ (ppm) *, Multiplicity **, and J Value (Hz) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| H7 | H8 | H9 | H10 | H11 | H12 | H14 | H16 | H18 | |
| 1 | 10.91, s (-OH) | 6.38, d, J = 2.3 | 9.84, s, (-OH) | 6.36, dd, J1 = 8.5, J2 = 2.3 | 7.53, d, J = 8.5 | 7.15, s, (-NH2) | - | - | - |
| 2 | 10.90, s (-OH) | 6.45, d, J = 2.3 |
9.92, s, (-OH) | 6.40, dd, J1 = 8.7, J2 = 2.3 |
7.91, d, J = 8.7 |
12.32, s, (-NH-) | 2.18, s | - | - |
| 3 | - | 7.29, d, J = 2.3 |
- | 7.26, dd, J1 = 8.5, J2 = 2.3 |
8.2, d, J = 8.5 |
12.68, s, (-NH-) |
2.22, s | 2.31, s | 2.38, s |
* = numbering system of atoms shown in Figure 1; ** s = singlet, d = doublet, dd = double doublet.