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Synergistic effects against S. aureus demonstrated by 1 and 5 upon their combination with kanamycin.
| Compound | MIC a (µg/mL) (±0.01) | Combination | MIC b (µg/mL) (±0.01) | FIC c |
|---|---|---|---|---|
| 1 | 500 | 1/kanamycin | 125 | 0.375 |
| kanamycin | 3.9 | 0.5 | ||
| 5 | 500 | 5/kanamycin | 125 | 0.375 |
| kanamycin | 3.9 | 0.5 |
a MIC = value determined in an individual compound (1, 5, and kanamycin); b MIC = value determined in a combination of two compounds (1 or 5 with kanamycin); c FIC = fractional inhibitory concentration [40].
