TABLE 3.
Diagnostic Performance of HbA1c ≥5.7% and FPG ≥100 mg/dL for Detecting Cardiometabolic Risk Factors, US Children and Adolescents Without Diagnosed Diabetes, NHANES 1999–2016
| HbA1c ≥5.7% | FPG ≥ 100 mg/dL | |||||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | |
| Obese, ≥95th percentile for age and sex | 4.4 (2.9–6.0) | 99.0 (98.7–99.3) | 50.7 (38.6–62.8) | 81.5 (80.0–83.0) | 16.2 (13.1–19.3) | 90.4 (89.1–91.7) | 28.5 (23.2–33.8) | 82.1 (80.5–83.6) |
| Metabolic syndromea | 4.0 (2.3–5.7) | 98.6 (98.3–98.9) | 25.7 (16.1–35.2) | 89.4 (88.3–90.5) | 19.6 (15.4–23.9) | 90.2 (88.9–91.5) | 19.5 (14.9–24.2) | 90.2 (89.2–91.3) |
| Waist circumference ≥90th percentile | 2.8 (1.8–3.7) | 98.8 (98.5–99.2) | 52.6 (40.7–64.5) | 68.3 (66.5–70.1) | 11.9 (9.9–14.0) | 89.5 (88.1–91.0) | 35.0 (29.6–40.4) | 68.3 (66.5–70.2) |
| Hypertension, ≥130/≥85 | 6.2 (2.9–9.6) | 98.5 (98.2–98.9) | 14.4 (6.4–22.5) | 96.4 (95.6–97.1) | 30.6 (21.7–39.4) | 90.0 (88.7–91.2) | 10.7 (7.1–14.3) | 97.0 (96.3–97.8) |
| Triglycerides ≥150 mg/dL | —b | —b | 17.3 (7.5–27.1) | 90.9 (89.8–92.0) | 18.8 (14.3–23.3) | 89.8 (88.6–91.0) | 15.9 (12.0–19.7) | 91.6 (90.5–92.6) |
| HDL-C <40 mg/dL | 3.1 (1.6–4.6) | 98.6 (98.2–98.9) | 26.1 (15.1–37.0) | 86.2 (84.9–87.4) | 18.0 (14.2–21.9) | 90.2 (88.9–91.5) | 23.1 (18.8–27.4) | 87.1 (85.7–88.4) |
| LDL-C ≥130 mg/dL | —b | —b | —b | 92.6 (91.7–93.6) | 14.5 (9.5–19.4) | 89.4 (88.1–90.6) | 9.9 (6.4–13.4) | 92.8 (91.9–93.8) |
—, not estimated.
a
Metabolic syndrome is defined as waist circumference ≥90th percentile for age, sex, or race and 1 of hypertension, hypertriglyceridemia, or hypoalphalipoproteinemia.
b
Sample size was too small to estimate with precision (SE ≥30% of estimate).