Table 2.
Associations of biological data with 30‐day increase of oxygenation requirements
| Biological data | 30‐day aggravation |
Unadjusted |
Adjusteda |
|||
|---|---|---|---|---|---|---|
| No (n = 172) | Yes (=71) | SHR (95% CI) | P | SHR (95% CI) | P | |
| O blood group, n (%) | 56 (42.1) | 21 (35.6) | 0.78 (0.46‐1.32)b | .35 | 0.80 (0.46‐1.39)b | .44 |
| Leucocytes/mm3 | 7676 ± 3796 | 7667 ± 3663 | .31f | .26f | ||
| 0‐5 daysd | 1.12 (0.89‐1.40) | .16 | 1.13 (0.89‐1.43) | .32 | ||
| 6‐30 daysd | 0.65 (0.31‐1.33) | .24 | 0.66 (0.32‐1.34) | .24 | ||
| Neutrophils/mm3 | 4700 (3600‐6500) | 5350 (4400‐7500) | 1.29 (0.96‐1.74)c | .090 | 1.19 (0.88‐1.61)c | .24 |
| Lymphocytes/mm3 | 1109 ± 646 | 927 ± 485 | 0.74 (0.54‐1.01) | .061 | 0.71 (0.50‐0.99) | .041 |
| Monocytes/mm3 | 500 (300‐700) | 400 (300‐700) | 0.97 (0.75‐1.25)c | .81 | 0.91 (0.72‐1.16)c | .44 |
| Platelets, G/L | 236 ± 120 | 214 ± 98 | .073f | .28f | ||
| 0‐5 daysd | 0.94 (0.73‐1.21) | .62 | 0.95 (0.72‐1.24) | .69 | ||
| 6‐30 daysd | 0.66 (0.45‐0.94) | .023 | 0.66 (0.43‐1.01) | .057 | ||
| Creatinine, mg/L | 8 (7‐11) | 10 (7‐12) | 1.20 (0.95‐1.51)c | .12 | 1.10 (0.83‐1.47)c | .48 |
| Lactate dehydrogenase, IU/L | 359 (280‐476) | 426 (312‐508) | 1.22 (0.96‐1.54)c | .090 | 1.11 (0.87‐1.43)c | .38 |
| Troponine ng/L | 14 (7‐26) | 16 (9‐24) | .25f | .50f | ||
| <8 | 41 (28.1) | 10 (17.2) | 1.00 (ref.) | ‐ | 1.00 (ref.) | ‐ |
| 8‐14 | 33 (22.6) | 17 (29.3) | 1.90 (0.88‐4.04) | .098 | 1.16 (0.61‐2.18) | .65 |
| 15‐25 | 34 (23.3) | 18 (31.0) | 1.99 (0.93‐4.23) | .075 | 1.19 (0.60‐2.31) | .62 |
| >25 | 38 (26.0) | 13 (22.5) | 1.36 (0.61‐3.04) | .46 | 0.71 (0.33‐1.53) | .38 |
| C‐reactive protein, mg/L | 60 (25‐111) | 101 (56‐143) | 1.68 (1.26‐2.23)c | <.001 | 1.66 (1.25‐2.19)c | <.001 |
| aPTT | 1.13 (1.00‐1.26) | 1.13 (1.06‐1.23) | 1.02 (0.85‐1.23)c | .82 | 1.02 (0.84‐1.24)c | .85 |
| PTr | 1.09 (1.04‐1.16) | 1.10 (1.05‐1.18) | 1.15 (0.98‐1.35)c | .081 | 1.10 (0.89‐1.38)c | .34 |
| D‐dimers, µg/mL | 1.00 (0.70‐1.80) | 1.00 (0.80‐1.90) | 1.04 (0.77‐1.40)c | .80 | 1.01 (0.74‐1.38)c | .95 |
| Fibrinogen, g/L | 5.9 ± 1.7 | 6.4 ± 1.5 | 1.32 (1.04‐1.68) | .021 | 1.34 (1.04‐1.74) | .022 |
| Factor VIII, IU/dL | 244 ± 104 | 233 ± 79 | 0.93 (0.73‐1.17) | .51 | 0.89 (0.71‐1.13) | .34 |
| VWF:Age, IU/dL | 351 ± 141 | 381 ± 98 | .30f | .39f | ||
| <270 | 44 (28.6) | 9 (15.5) | 1.00 (ref.) | ‐ | 1.00 (ref.) | ‐ |
| 270‐354 | 35 (22.7) | 17 (29.3) | 2.09 (0.94‐4.60) | .068 | 1.71 (0.77‐3.78) | .18 |
| 355‐430 | 38 (24.7) | 16 (27.6) | 1.86 (0.83‐4.14) | .13 | 1.86 (0.87‐3.93) | .11 |
| >430 | 37 (24.0) | 16 (27.6) | 1.94 (0.86‐4.35) | .11 | 1.80 (0.82‐3.97) | .14 |
| FVIII/VWF:Ag ratio | 0.74 ± 0.27 | 0.64 ± 0.24 | 0.70 (0.52‐0.96) | .025 | 0.71 (0.51‐0.98) | .036 |
Note
Values are median (interquartile range) or means ± standard deviation. SubHazard ratios (SHRs) were calculated using Fine and Gray models taking into account the mortality in the context of withholding or withdrawal of life‐sustaining treatment (n = 16) as competing events and were expressed per one standard deviation unless otherwise as indicated.
Abbreviations: aPTTr, activated partial thromboplastin time ratio; CI, confidence interval; CRP, C‐reactive protein; FVIII, factor VIII activity; PTr, prothrombin time ratio; SD, standard deviation; SHR, subhazard ratio; VWF: Ag, von Willebrand factor antigen.
Adjusted for age, sex, body mass index, hypertension, and diabetes calculated after handling missing values (in biological and confounding factors) by multiple imputation.
SHR calculated for O versus others blood groups.
SHR calculated per one standard deviation in log‐transformed values.
Modeled with time‐dependent coefficients to accommodate deviation in proportional subhazard assumption.
Modeled as categorical variables based on quartiles to accommodate deviation in log linear relationship.
P‐value for overall effect calculated using a likelihood ratio test.