. 2022 Dec 21;18(11):2942–2953. doi: 10.1111/jth.15067

Table 3.

Associations of biological data with 30‐day thrombotic events

Biological data	30‐day thrombotic events		Unadjusted		Adjusted^a
Biological data	No (n = 212)	Yes (=31)	SHR (95% CI)	P	SHR (95% CI)	P
O blood group, n (%)	67 (41.6)	10 (32.3)	0.69 (0.32‐1.45)^b	.32	0.76 (0.35‐1.61)^b	.47
Leucocytes/mm³	7542 ± 3784	8512 ± 3461		.070^e		.14^e
0‐5 days^d			1.36 (1.04‐1.76)	.022	1.50 (1.11‐2.03)	.008
6‐30 days^d			1.02 (0.72‐1.45)	.89	1.11 (0.74‐1.65)	.60
Neutrophils/mm³	4900 (3600‐6500)	6550 (5200‐8200)	1.40 (1.06‐1.84)^c	.018	1.42 (1.03‐1.95)^c	.031
Lymphocytes/mm³	1070 ± 633	974 ± 368	0.85 (0.60‐1.20)	.36	0.92 (0.60‐1.40)	.69
Monocytes/mm³	400 (300‐700)	400 (200‐800)		.086^e		.35^e
0‐5 days^d			1.47 (0.79‐2.73)^c	.22	1.28 (0.53‐3.07)^c	.57
6‐30 days^d			0.72 (0.51‐1.02)^c	.064	0.75 (0.50‐1.11)^c	.15
Platelets, G/L	226 ± 112	246 ± 120		.020^e		.053^e
0‐5 days^d			1.71 (1.11‐2.62)	.014	1.71 (1.10‐2.66)	.016
6‐30 days^d			0.78 (0.52‐1.18)	.23	0.78 (0.51‐1.18)	.24
Creatinine, mg/L	8.5 (7‐11.5)	8.0 (6‐11)	0.84 (0.58‐1.21)^c	.35	0.92 (0.62‐1.34)^c	.64
Lactate dehydrogenase, IU/L	360 (280‐456)	495 (383‐599)	1.79 (1.36‐2.36)^c	<.001	1.87 (1.36‐2.58)^c	<.001
Troponin, ng/L	15.0 (7.5‐26.0)	11.5 (7.5‐23.0)	1.08 (0.69‐1.70)^c	.73	1.35 (0.84‐2.15)^c	.21
C‐reactive protein, mg/L	69 (31‐123)	79 (28‐157)	1.08 (0.71‐1.62)^c	.73	1.20 (0.77‐1.86)^c	.40
aPTTr	1.10 (1.03‐1.23)	1.17 (1.03‐1.26)	1.25 (0.89‐1.73)^c	.19	1.10 (0.71‐1.72)^c	.66
PTr	1.09 (1.04‐1.15)	1.15 (1.08‐1.20)	1.13 (0.94‐1.35)^c	.17	1.10 (0.83‐1.46)^c	.51
D‐dimers, µg/mL	1.00 (0.70‐1.60)	1.60 (1.10‐4.20)		<.001^e		<.001^e
0‐5 days^d			2.48 (1.66‐3.70)^c	<.001	2.90 (1.86‐4.50)^c	<.001
6‐30 days^d			1.01 (0.31‐3.30)^c	.99	1.21 (0.33‐4.40)^c	.77
Fibrinogen, g/L	6.1 ± 1.6	5.9 ± 1.8	0.90 (0.60‐1.32)	.31	0.96 (0.65‐1.41)	.84
Factor VIII, IU/dL	239 ± 91	251 ± 123		<.001^e		.007^e
0‐5 d^d			1.78 (1.17‐2.68)	.006	1.72 (1.15‐2.55)	.007
6‐30 days^d			0.46 (0.26‐0.82)	.008	0.50 (0.27‐0.91)	.022
VWF:Ag, IU/dL	358 ± 131	381 ± 107	1.18 (0.90‐1.55)	.22	1.23 (0.92‐1.63)	.16
FVIII/VWF:Ag ratio	0.72 ± 0.27	0.67 ± 0.29		.035^e		.063^e
0‐5 days^d			1.23 (0.69‐2.16)	.48	1.09 (0.61‐1.92)	.77
6‐30 days^d			0.47 (0.25‐0.87)	.015	0.47 (0.26‐0.85)	.012

Note

Values are median (interquartile range) or means ± standard deviation. Subhazard ratios (SHRs) were calculated using Fine and Gray models taking into account the mortality (n = 27) as competing events and were expressed per one standard deviation unless otherwise as indicated.

Abbreviations: aPTTr, activated partial thromboplastin time ratio; CI, confidence interval; CRP, C‐reactive protein; FVIII, factor VIII activity; PTr, prothrombin time ratio; SD, standard deviation; SHR, subhazard ratio; VWF:Ag, von Willebrand factor antigen.

^{^a}

Adjusted for age, sex, body mass index, hypertension, and diabetes calculated after handling missing values (in biological and confounding factors) by multiple imputation.

^{^b}

SHR calculated for O versus others blood groups.

^{^c}

SHR calculated per one standard deviation in log‐transformed values.

^{^d}

Modeled with time‐dependent coefficients to accommodate deviation in proportional subhazard assumption.

^{^e}

P‐value for overall effect calculated using a likelihood ratio test.