Table 2.
Laboratory findings of COVID‐19 patients on admission between severe group and nonsevere group
| Disease severity | ||||
|---|---|---|---|---|
| Median (IQR) | All patients (n = 222) | Nonsevere (n = 202) | Severe (n = 20) | P value |
| Blood routine | ||||
| White blood cell count, ×109/L | 6.2 (5.2‐7.5) | 6.2 (5.2‐7.5) | 6.4 (5.7‐8.4) | .346 |
| Lymphocyte count, ×109/L | 1.7 (1.3‐2.2) | 1.8 (1.4‐2.2) | 0.87 (0.71‐1.5) | .000 |
| Neutrophil count, ×109/L | 3.7 (3‐5) | 3.6 (3‐4.8) | 5.2 (3.5‐7.1) | .014 |
| Monocyte count, ×109/L | 0.47 (0.37‐0.57) | 0.47 (0.37‐0.56) | 0.48 (0.36‐0.61) | .884 |
| Eosinophil count, ×109/L | 0.08 (0.05‐0.16) | 0.09 (0.06‐0.16) | 0.03 (0.01‐0.08) | .000 |
| Basophils count, ×109/L | 0.01 (0.01‐0.02) | 0.01 (0.01‐0.02) | 0.01 (0‐0.02) | .050 |
| Red blood cell count, ×109/L | 4.3 (3.9‐4.6) | 4.3 (3.9‐4.6) | 3.8 (3.6‐4.2) | .002 |
| Hemoglobin, g/L | 127.0 (116.0‐137.0) | 128 (118‐137) | 111.5 (104‐128.3) | .002 |
| Hematocrit | 39.0 (35.7‐41.6) | 39.1 (36.3‐41.7) | 34.1 (31.9‐39.7) | .003 |
| Platelet count, ×109/L | 228.0 (183.0‐279.8) | 229.5 (188‐280.8) | 193.0 (169.5‐267.3) | .106 |
| PaO2, mm Hg | 92.5 (77.5‐138.8) | 89.0 (76.0‐131.0) | 95.0 (86.5‐186.5) | .292 |
| SaO2, % | 98.0 (97.0‐99.0) | 98.0 (97.0‐98.3) | 98.0 (97.0‐100.0) | .291 |
| Coagulation function | ||||
| Prothrombin time, s | 11 (10.7‐11.6) | 11 (10.6‐11.5) | 11.4 (11.1‐12.2) | .013 |
| Activated partial thrombin time, s | 27.4 (25.3‐30.2) | 27.4 (25.3‐30.1) | 28 (25.3‐33.4) | .510 |
| D‐dimer, μg/mL | 0.5 (0.3‐0.63) | 0.5 (0.3‐0.6) | 0.9 (0.5‐1.4) | .000 |
| Inflammation profile | ||||
| C‐reactive protein, mg/L | 1.9 (1.5‐3.9) | 1.8 (1.5‐3) | 46.8 (2.8‐76) | .000 |
| Procalcitonin, ng/mL | 0.02 (0.01‐0.07) | 0.02 (0.01‐0.06) | 0.06 (0.02‐0.46) | .005 |
| Blood lactic acid, mmol/L | 1.4 (1‐1.9) | 1.3 (1‐1.9) | 1.6 (1‐2) | .769 |
| ESR, mm/h | 11 (6.5‐23.5) | 10 (6‐21) | 42 (22.3‐73) | .005 |
| Cardiac function | ||||
| Myoglobin, ng/mL | 18 (11.2‐35.4) | 18 (11.2‐34.1) | 21.5 (10‐42.4) | .719 |
| CK‐MB, μg/mL | 2.6 (1‐7.5) | 2.6 (1.1‐8.5) | 2.5 (1‐4) | .476 |
| LDH, U/L | 178 (145.3‐211.8) | 173 (144.5‐203.5) | 261 (204‐395.5) | .000 |
| T‐pro‐BNP, pg/mL | 120 (16‐1422) | 88 (15‐489.8) | 524 (31.3‐1876.5) | .242 |
| Liver function | ||||
| ALT, U/L | 18 (13‐30.8) | 18 (13‐30) | 27 (11.8‐32.5) | .465 |
| AST, U/L | 22.5 (18‐28) | 22 (18‐28) | 31.5 (17.8‐48.3) | .027 |
| Total bilirubin, μmol/L | 10.1 (8.3‐13.3) | 9.8 (8.2‐13.1) | 14.5 (10.4‐18.5) | .001 |
| ALP, U/L | 83 (70‐102) | 83 (70‐101) | 79 (69.5‐103.3) | .704 |
| GGT, U/L | 20 (12.3‐30.8) | 18.5 (12‐28) | 27.5 (18.8‐40.3) | .064 |
| Renal function | ||||
| BUN, mmol/L | 4.4 (3.7‐5.8) | 4.3 (3.7‐5.6) | 5.9 (3.6‐7.5) | .044 |
| Creatinine ≥133 μmol/L—no., % | 6 (2.7) | 3 (1.5) | 3 (15.0) | .000 |
| Uric acid, μmol/L | 289 (240‐353) | 289 (236‐349) | 296 (259.5‐400.5) | .351 |
Note: Data are presented as no./total no. (%) and median (IQR), P values were calculated by the Mann‐Whitney U test, t test, χ 2 test, or Fisher's exact test, as appropriate. P values denoted the comparison between severe and nonsevere groups.
Abbreviations: ALP, alkaline phosphatase; ALT, glutamic‐pyruvic transaminase; AST, glutamic oxiracetam transaminase; BUN, urea nitrogen; CK‐MB, creatine kinase‐MB; COVID‐19, coronavirus disease 2019; ESR, erythrocyte sedimentation rate; GGT, gamma‐glutamyl transpeptidase; LDH, lactate dehydrogenase; PaO2, partial pressure of oxygen; SaO2, oxygen saturation; T‐pro‐BNP, T‐pro brain natriuretic peptide.