Table 3.
Association of depression history with low levels of anti-müllerian hormone (≤1.4 ng/mL), stratified by oral contraceptive use, parity, cycle regularity, smoking and body mass index (BMI), Harvard Study of Moods and Cycles, 1995–1998
| AMH Level (≤1.4 ng/mL) | Age-Adjusted | Multivariable Ɨ | |||
|---|---|---|---|---|---|
| n | % | PRa | Adjusted PR (95% CI) | ||
| Age, years | |||||
| 36–40 | 85 | 45.2 | 0.74 | 0.75 | (0.52, 1.09) |
| 41–45 | 128 | 70.7 | 1.11 | 1.16 | (0.95, 1.40) |
| Parity (livebirths) c | |||||
| Parous | 117 | 58.5 | 1.07 | 1.08 | (0.85, 1.38) |
| Nulliparous | 96 | 56.8 | 0.78 | 0.77 | (0.59, 1.00) |
| Infertility | |||||
| Fertile | 178 | 58.8 | 0.96 | 0.98 | (0.81, 1.18) |
| Infertile | 35 | 53.0 | 0.58 | 0.65 | (0.32, 1.33) |
| Cycle regularity b,c | |||||
| Regular Cycle | 191 | 56.2 | 0.97 | 0.96 | (0.80, 1.16) |
| Irregular Cycle | 22 | 75.9 | 0.75 | 0.70 | (0.38, 1.29) |
| Baseline smoking status | |||||
| Ever-smokers | 29 | 55.8 | 0.68 | 0.79 | (0.50, 1.26) |
| Never-smokers | 184 | 58.0 | 0.97 | 0.96 | (0.80, 1.16) |
| Body mass index (BMI), kg/m2 | |||||
| Normal weight (< 25) | 128 | 56.9 | 0.87 | 0.85 | (0.68, 1.08) |
| Overweight (25-29.9) | 55 | 59.8 | 1.19 | 1.22 | (0.85, 1.73) |
| Obese (≥30) | 30 | 57.7 | 0.75 | 0.80 | (0.48, 1.35) |
Ɨ Covariates included age, age at menarche, irregular cycle, pack years smoking, and body mass index (BMI)
a. ‘Age-adjusted’ model reports crude prevalence ratios for stratified age-groups
b. Did not adjust for parity
c. Did not adjust for oral contraceptive use