Table 3.
The intussusception cases and case ratios during post-rotavirus vaccine introduction period compared to pre-introduction periods
| Post-RVV period (Apr- Sep 2017) |
Pre-RVV period (Oct 2016 - Mar 2017) |
Pre-RVV period (Apr- Sep 2016) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Region (number of sites)a | No of cases | IS case rate | No of cases | IS case ratio | RR (95% CI) for cases | RR (95% CI) for IS case rate | No of cases | IS ratio | RR (95% CI) for cases | RR (95% CI) for IS case rate |
| East (n = 2)a | 20 | 20.4 | 29 | 29.9 | 0.69 (0.33–1.2) | 0.67 (0.3–1.28) | 45 | 34.6 | 0.44 (0.2–1.15) | 0.58 (0.32–1.2) |
| North (n = 1)a | 0 | 0 | 2 | 27.4 | – | – | 3 | 37.5 | – | – |
| South (n = 1)a | 6 | 13.3 | 8 | 20.4 | 0.75 (0.45–1.24) | 0.65 (0.48–1.23) | 11 | 26.4 | 0.55 (0.28–1.2) | 0.51 (0.3–1.22) |
| Pooled (n = 4)a | 26 | 16.3 | 39 | 27.2 | 0.67 (0.34–1.19) | 0.6 (0.3–1.18) | 59 | 32.8 | 0.44 (0.22–1.18) | 0.5 (0.3–1.2) |
Note: IS Intussusception, Intussusception (IS) case rate Intussusception cases per 1000 paediatric surgery admission, RVV Rotavirus vaccine, RR risk ratio with 95% confidence interval (CI), RVV: Rotavirus vaccine
The comparison includes the data from four study sites in three states
aNumbers in the bracket with the regions indicate the numbers of study sites per region where RVV was introduced
Post-RVV period: April 2017 to September 2017 (6 months)
Pre-RVV period: Comparison has been done for two pre-intervention periods of 6 months each; October 2016 to March 2017- the immediate pre-RVV introduction period and April 2016 to September 2016- the calendar months comparable period during the previous year