Fig. 2.

Comparison of base editing activity and precision using eA3G-BE and other precise BEs. a Schematic representation of six base editors’ architecture. YE1 (bearing W90Y+R126E mutations in rA1), YEE (bearing W90Y+R126E+R132E mutations in rA1), and eA3A (bearing N57G mutation in hA3A). b–d Heat maps showing C-to-T editing efficiencies for six base editors at Emx1-1 (b), Fancf (c), and Emx1-3(d). The CC or CCC context was shown in red triangle or green triangle, respectively. Values and error bars reflect the mean ± s.e.m. of three independent biological replicates