TABLE 4.
Cox Proportional Hazards Model Comparing the Risk of Incident Diagnosis of Hypertension Among Individuals Initiating New Medications for RAa
| Incident Hypertension Total Obs = 6881 Person-Years = 19,583 |
||
|---|---|---|
| Hazard Ratio (95% CI) | P | |
| Methotrexate | Reference | — |
| Prednisone | 1.30 (1.08–1.56) | 0.006 |
| Leflunomide | 1.52 (1.21–1.91) | <0.001 |
| TNFi | 1.36 (1.11–1.67) | 0.003 |
| Sulfasalazine | 1.03 (0.78–1.35) | 0.84 |
| Hydroxychloroquine | 0.86 (0.69–1.08) | 0.20 |
a
Adjusted for age, sex, race, BMI, CRP, Rheumatic Disease Comorbidity Index, current smoking, lung disease, interstitial lung disease, diabetes mellitus, any malignancy, lung cancer, CHF, CKD, history of myocardial infarction, disease duration greater than 5 years, ACPA seropositivity, RF seropositivity, concurrent RA drug use, current SBP and DBP, and prior change in SBP and DBP.