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. 2020 Aug 14;21(16):5832. doi: 10.3390/ijms21165832

Figure 5.

Figure 5

Typical QCM-D spectra of the shifts in frequency (Δf) and dissipation factor (ΔD) recorded during subsequent steps of Au/PEI-βCD-αCD-FA (A) and Au/PEI (B) modification by DOX and beta-LP. Inset: Typical QCM-D spectra of the shifts in frequency (Δf) and dissipation factor (ΔD) recorded during electrodeposition of PEI-βCD-αCD-FA and its stabilization. Experimental conditions: 0.02 M PBS (pH 7.4); CPEI-βCD-αCD = 0.25 mg·mL−1; CDOX = 100 µM; Cbeta-LP = 100 µM. (1) Electrodeposition of PEI-βCD-αCD-FA (A) and PEI (B); (2) stabilization of PEI-βCD-αCD-FA (A) and PEI (B) layer in PBS buffer pH 7.4; (3) loading of DOX to PEI-βCD-αCD-FA (A) and PEI (B); (4) removing of unbounded DOX with PBS buffer pH 7.4; (5) loading of beta-LP to PEI-βCD(DOX)-αCD-FA (A) and PEI (B); (6) removing of unbounded beta-LP with PBS buffer pH 7.4; (7) degradation of PEI-βCD(DOX)-αCD(beta-LP)-FA at pH 5.5 (0.02 M PB buffer); (8) degradation of PEI-βCD(DOX)-αCD(beta-LP)-FA at pH 4.0 (0.02 M PB buffer).