Table 6.

Summary of key changes reported in the menisci across the four different animal models over time.

Time Point	ACLT	Meniscectomy	Combination	Impact
Early	Fibrillation observed in both hemjoints, with tears being more common in the medial meniscus. Decrease in GAG	No data	No data	No data
Mid-Early	Greater changes in morphology in medial meniscus and significant changes in mechanical properties	No data	Damage to both menisci accompanied by a decrease in mechanical properties	Damage and complex tears to both menisci
Mid-Late	Progression of tears in medial meniscus, more commonly in posterior region, and decrease in GAG staining	No data	Damage progressed in both menisci accompanied by decrease in mechanical properties and GAG content	Damage and complex tears to both menisci
Late	Severe tears in both menisci	No data	Further damage to both menisci and decrease in mechanical properties and GAG content	Damage to both menisci accompanied by a decrease in mechanical properties and GAG coverage