Figure 2.

Intragraft leukocyte infiltration associates with ABMR histology. (A) Heatmap of Spearman correlation coefficients between absolute leukocyte infiltration and severity of histologic lesions in patients who are HLA-DSA negative (DSAneg; n=140) and those who are HLA-DSA positive (DSApos; n=84). Marked boxes indicate statistical significance (P<0.05). (B and C) Receiver operating characteristic curves depicting diagnostic accuracy of (B) lymphoid and (C) myeloid cell infiltration for and between ABMRh subtypes. Infiltration of NK cells, monocytes/macrophages, and CD8-positive T cells had the highest predictive value for ABMRh, regardless of HLA-DSA status. The heatmap for the entire population and receiver operating characteristic curves for ABMRh are depicted in Supplemental Figure 2. Mϕ, macrophage.