Figure 5.

ABMR gene subset expression correlates with humoral lesion severity. Clustering of biopsy specimens based on expression of selective gene sets, with labeling based on the histomorphologic humoral lesion score (i.e., sum of glomerulitis, peritubular capillaritis, arteritis, C4d and transplant glomerulopathy). In both patients who were HLA-DSA positive (n=84) and HLA-DSA negative (n=140), ADCC, NK cell, and ABMR transcripts associate with severity of humoral scores. t-SNE is used for dimensionality reduction. Points represent biopsy specimens.