Table 2.
Comparison of histologic features between phenotypes
| Parameter | No ABMRh (n=168) | ABMRh (n=56) | P Value | HLA-DSA Negative ABMRh (n=26) | HLA-DSA Positive ABMRh (n=30) | P Value |
|---|---|---|---|---|---|---|
| g, mean (±SD) | 0.05 (±0.22) | 1.95 (±0.94) | <0.001a | 2.19 (±0.80) | 1.73 (±1.01) | 0.09 |
| g≥1, n (%) | 9/168 (5.4) | 53/56 (94.6) | <0.001a | 26/26 (100.0) | 27/30 (90.0) | 0.24 |
| ptc, mean (±SD) | 0.09 (±0.43) | 1.07 (±0.89) | <0.001a | 1.12 (±0.82) | 1.03 (±0.96) | 0.66 |
| ptc≥1, n (%) | 9/168 (5.4) | 39/56 (69.6) | <0.001a | 20/26 (76.9) | 19/30 (63.3) | 0.27 |
| MVI score, mean (±SD) | 0.14 (±0.47) | 3.01 (±1.30) | <0.001a | 3.31 (±1.09) | 2.77 (±1.43) | 0.13 |
| MVI ≥2, n (%) | 4/168 (2.4) | 49/56 (87.5) | <0.001a | 25/26 (96.2) | 24/30 (80.0) | 0.11 |
| C4d, mean (±SD) | 0.12 (±0.55) | 0.84 (±1.16) | <0.001a | 0.46 (±0.81) | 1.17 (±1.32) | 0.04a |
| C4d≥1, n (%) | 9/168 (5.4) | 24/56 (42.9) | <0.001a | 8/26 (30.8) | 16/30 (53.3) | 0.09 |
| v, mean (±SD) | 0.04 (±0.22) | 0.38 (±0.65) | <0.001a | 0.42 (±0.58) | 0.33 (±0.71) | 0.29 |
| v≥1, n (%) | 5/168 (3.0) | 17/56 (30.4) | <0.001a | 10/26 (38.5) | 7/30 (23.3) | 0.22 |
| cg, mean (±SD) | 0.07 (±0.41) | 0.40 (±0.81) | <0.001a | 0.35 (±0.63) | 0.45 (±0.95) | 0.94 |
| cg≥1, n (%) | 7/168 (4.2) | 14/56 (25.0) | <0.001a | 7/26 (26.9) | 7/30 (23.3) | 0.77 |
| i, mean (±SD) | 0.24 (±0.65) | 0.63 (±1.05) | 0.006a | 0.77 (±1.21) | 0.50 (±0.90) | 0.42 |
| i≥1, n (%) | 25/168 (14.9) | 17/56 (30.4) | 0.01a | 9/26 (34.6) | 8/30 (26.7) | 0.52 |
| t, mean (±SD) | 0.44 (±0.76) | 0.70 (±0.76) | 0.004a | 0.69 (±0.88) | 0.70 (±0.65) | 0.65 |
| t≥1, n (%) | 52/168 (31.0) | 30/56 (53.6) | 0.003a | 12/26 (46.2) | 18/30 (60.0) | 0.30 |
| ti, mean (±SD) | 0.38 (±0.79) | 0.57 (±0.87) | 0.04a | 0.46 (±0.86) | 0.67 (±0.88) | 0.30 |
| ti≥1, n (%) | 38/168 (22.6) | 21/56 (37.5) | 0.03a | 8/26 (30.8) | 13/30 (43.3) | 0.33 |
| ci, mean (±SD) | 0.94 (±1.10) | 0.68 (±0.79) | 0.30 | 0.54 (±0.71) | 0.80 (±0.85) | 0.25 |
| ci≥1, n (%) | 87/168 (51.8) | 24/56 (42.8) | 0.58 | 11/26 (42.3) | 17/30 (56.7) | 0.28 |
| ct, mean (±SD) | 1.01 (±1.01) | 0.80 (±0.72) | 0.40 | 0.73 (±0.67) | 0.87 (±0.78) | 0.58 |
| ct≥1, n (%) | 103/168 (61.3) | 36/56 (64.3) | 0.69 | 16/26 (61.5) | 20/30 (66.7) | 0.69 |
| ah, mean (±SD) | 0.85 (±0.99) | 1.04 (±1.11) | 0.32 | 1.08 (±1.06) | 1.00 (±1.17) | 0.61 |
| ah≥1, n (%) | 88/168 (52.4) | 32/56 (57.1) | 0.54 | 17/26 (65.4) | 15/30 (50.0.4) | 0.25 |
| cv, mean (±SD) | 0.83 (±0.95) | 1.20 (±1.15) | 0.04a | 1.42 (±1.21) | 1.00 (±1.08) | 0.19 |
| cv≥1, n (%) | 87/168 (51.8) | 35/56 (62.5) | 0.16 | 18/26 (70.8) | 17/30 (56.7) | 0.33 |
| TCMR, n (%) | 10/168 (6.0) | 14/56 (25.0) | <0.001a | 8/26 (30.8) | 6/30 (20.0) | 0.35 |
| Borderline, n (%) | 20/168 (11.9) | 6/56 (10.7) | 0.81 | 2/26 (7.7) | 4/30 (13.3) | 0.68 |
| IFTA, n (%) | 80/168 (47.6) | 24/56 (42.9) | 0.54 | 11/26 (42.3) | 13/30 (43.3) | 0.94 |
| PVAN, n (%) | 2/168 (1.2) | 1/56 (1.8) | >0.99 | 0/26 (0.0) | 1/30 (3.3) | >0.99 |
| ATN, n (%) | 34/168 (20.2) | 22/56 (39.3) | 0.004a | 9/26 (34.6) | 13/30 (43.3) | 0.51 |
| GN, n (%) | 1/168 (0.6) | 3/56 (5.4) | 0.05a | 2/26 (7.7) | 1/30 (3.3) | 0.59 |
| TMA, n (%) | 3/168 (1.8) | 6/56 (10.7) | 0.009a | 3/26 (11.5) | 3/30 (10.0) | >0.99 |
| Pyelonephritis, n (%) | 3/168 (1.8) | 0/56 (0.0) | 0.57 | 0/24 (0.0) | 0/30 (0.0) | >0.99 |
Denominator numbers less than original group size indicate missing data. Percentage values may not add up to 100% due to rounding. g, glomerulitis; ptc, peritubular capillaritis; v, intimal arteritis; i, interstitial inflammation; t, tubulitis; ti, total inflammation; ci, interstitial fibrosis; ct, tubular atrophy; ah, arteriolar hyalinosis; cv, vascular fibrous intimal thickening; IFTA, interstitial fibrosis and tubular atrophy; PVAN, polyomavirus-associated nephropathy; ATN, acute tubular necrosis; TMA, thrombotic microangiopathy.
a
Indicates significance P values for difference between groups.