Table 3.
Cox proportional hazards analysis of allograft failure (n=224)
| Factor | No. of Patients | No. of Events | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | |||
| HLA-DSA ABMRh | ||||||
| No ABMRh | 168 | 16 | 1 | 1 | ||
| HLA-DSA–negative ABMRh | 26 | 6 | 2.57 (1.00 to 6.58) | 0.05a | 2.33 (0.85 to 6.33) | 0.10 |
| HLA-DSA–positive ABMRh | 30 | 12 | 5.39 (2.55 to 11.43) | <0.001a | 7.24 (3.04 to 17.20) | <0.001a |
| C4d score | 224 | 34 | 1.08 (0.74 to 1.57) | 0.69 | 0.68 (0.43 to 1.06) | 0.09 |
| Cellular rejection | ||||||
| None | 174 | 21 | 1 | 1 | ||
| Borderline | 26 | 5 | 1.72 (0.65 to 4.56) | 0.28 | 1.76 (0.66 to 4.68) | 0.26 |
| TCMR | 24 | 8 | 3.27 (1.45 to 7.39) | 0.004a | 2.09 (0.88 to 4.99) | 0.10 |
a
Indicates significance P values for difference between groups.