Table 1.
Summary of cytotoxicity phenotypes induced by APOL1 variants
| APOL1 Allele | Decrease in Cell Viability (14 d) | Increase Cellular Swelling (8-24 h) | K+ Efflux (8 h) | SAPK Activation (8 h) | Mitochondrial Dysfunction (24 h) | Phosphorylation of eIF2a (8 h) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tet Dose | Low | Inter | High | Inter | High | Low | Inter | High | Inter | High | Low | Inter | High | Inter | High |
| G0 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| G1 | + | +++ | +++ | ++ | +++ | — | +++ | +++ | — | +++ | — | + | +++ | — | ++ |
| G2 | — | +++ | +++ | ++ | +++ | — | +++ | +++ | — | +++ | — | + | +++ | — | ++ |
| G0G0 | — | — | + | — | — | — | — | + | — | — | — | + | +++ | — | — |
| G0G1 | + | +++ | +++ | ++ | +++ | — | ++ | +++ | — | +++ | — | ++ | +++ | + | ++ |
| G0G2 | — | +++ | +++ | ++ | +++ | — | +++ | +++ | — | +++ | — | ++ | +++ | + | ++ |
Low, Inter (intermediate), and High refer to low, intermediate and high expression of APOL1. –, absent; +, marginally present; ++, moderately present; +++, highly present.