Figure 2.

AREG-deficient mice are protected from NTN. (A) PAS-stained sections of nephritic kidneys from the indicated strains of mice at day 10 of NTN (original magnification ×400). (B and C) Quantification of (B) glomerular crescents and (C) interstitial injury at the indicated time points after NTN. (D) Albumin-creatinine ratio in the urine of indicated mouse strains at days 7 and 10 of NTN. (E) BUN levels of indicated mouse strains at 7 and 10 days after NTN induction. Symbols represent individual animals, horizontal lines show mean values. *P<0.05; **P<0.01; ***P<0.001. PAS, periodic acid–Schiff; WT, wild-type.