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. 2020 Jul 2;31(9):1996–2012. doi: 10.1681/ASN.2019111215

Figure 8.

Figure 8.

Lack of EGFR signaling in M/M attenuates nephritis. (A) PAS-stained sections of nephritic kidneys from the indicated strains of mice at day 7 (original magnification ×200). (B) Quantification of glomerular crescents and interstitial injury. (C) Albumin-creatinine ratio in the urine of mice from the indicated strains. (D) Quantification of renal glomerular and interstitial M/M infiltration during NTN by immunohistochemistry. (E) Quantification and representative FACS plot of renal Ly6Chigh inflammatory M/M of the indicated strains of mice. (F) Quantification and representative FACS plot of renal CCR2+ inflammatory M/M of the indicated strains of mice. (G) Semiquantitative analyses of renal mRNA expression of the indicated chemokines or cytokines by real-time quantitative PCR. (H) Quantification and representative FACS plot of apoptosis from blood M/M of naïve mice with the indicated genotypes. Symbols represent individual animals, horizontal lines show mean values. *P<0.05; **P<0.01; ***P<0.001. PAS, periodic acid–Schiff.