Table 3.
Harrell C-statistics, evaluating the discriminative ability of HLA mismatch calculations for dnDSA occurrence (n=926)
| HLA Mismatch Models | dnDSA Occurrence | |
|---|---|---|
| Univariable C-Statistic (95% CI)a | Multivariable C-Statistic (95% CI)a,b | |
| Overall dnDSA occurrence | ||
| HLA-A/B/DR antigens | 0.60 (0.51 to 0.69) | 0.71 (0.67 to 0.83) |
| HLA-A/B/DR/DQ antigens | 0.61 (0.52 to 0.70) | 0.71 (0.66 to 0.84) |
| Total antibody-verified eplets | 0.61 (0.53 to 0.71) | 0.72 (0.68 to 0.84) |
| DQ antibody-verified eplets | 0.65 (0.55 to 0.76) | 0.74 (0.69 to 0.85) |
| HLA-A/B/DR/DQ antigens and DQ antibody-verified eplets | 0.66 (0.56 to 0.77) | 0.74 (0.70 to 0.86) |
| HLA molecule-specific dnDSA occurrence | ||
| DQ antibody-verified eplets | 0.81 (0.73 to 0.89) | 0.89 (0.87 to 0.96) |
a
95% CIs are calculated based on 1000 bootstrapped samples.
b
Multivariable models were corrected for donor and recipient sex, donor and recipient age, recipient race, recipient body mass index, donor type, cold ischemia time, repeat transplantation, and pretransplant HLA antibodies (absence, non-DSA HLA antibodies, and DSA).