Table 1.
Baseline characteristics of SPRINT participants, stratified by baseline eGFR and UACR
| Variable | eGFR, ml/min per 1.73 m2 | UACR, mg/g | ||||
|---|---|---|---|---|---|---|
| <60 (n=2645) | ≥60 (n=6716) | P Value | ≥30 (n=1730) | <30 (n=7182) | P Value | |
| Age, mean±SD, yr | 71.9±9.3 | 66.3±9.0 | <0.001 | 70.3 (10.1) | 67.4 (9.2) | <0.001 |
| Female sex, n (%) | 1058 (40.0) | 2274 (33.9) | <0.001 | 579 (33.5) | 2568 (35.8) | 0.07 |
| Race/ethnicity, n (%) | <0.001 | 0.04 | ||||
| White | 1777 (67.2) | 3622 (53.9) | 995 (57.5) | 4120 (57.4) | ||
| Black | 637 (24.1) | 2165 (32.2) | 552 (31.9) | 2138 (29.8) | ||
| Hispanic | 190 (7.2) | 794 (11.8) | 154 (8.9) | 789 (11.0) | ||
| Other | 41 (1.6) | 134 (2.0) | 29 (1.7) | 135 (1.9) | ||
| Education, n (%) | <0.001 | 0.003 | ||||
| <High school | 294 (11.1) | 582 (8.7) | 190 (11.0) | 646 (9.0) | ||
| High school diploma | 457 (17.3) | 1063 (15.9) | 301 (17.4) | 1161 (16.2) | ||
| Post high school | 902 (34.1) | 2411 (36.0) | 629 (36.4) | 2542 (35.4) | ||
| College degree | 992 (37.5) | 2644 (39.5) | 610 (35.3) | 2833 (39.5) | ||
| Smoking status, n (%) | <0.001 | 0.02 | ||||
| Never smoker | 1206 (45.6) | 2917 (43.6) | 710 (41.1) | 3206 (44.7) | ||
| Former smoker | 1217 (46.0) | 2756 (41.2) | 786 (45.5) | 3011 (42.0) | ||
| Current smoker | 221 (8.4) | 1019 (15.2) | 232 (13.4) | 958 (13.4) | ||
| Alcohol, n (%) | <0.001 | 0.02 | ||||
| Heavy drinker | 226 (9.0) | 865 (13.5) | 184 (11.2) | 854 (12.5) | ||
| Light drinker | 538 (21.4) | 1382 (21.6) | 320 (19.4) | 1509 (22.1) | ||
| Moderate drinker | 416 (16.6) | 1332 (20.9) | 332 (20.2) | 1325 (19.4) | ||
| Nondrinker | 1331 (53.0) | 2810 (43.9) | 811 (49.2) | 3150 (46.1) | ||
| History of CVD, n (%) | 644 (24.4) | 1233 (18.4) | <0.001 | 423 (24.5) | 1381 (19.2) | <0.001 |
| ACE inhibitor use, n (%) | 1066 (40.3) | 2390 (35.6) | <0.001 | 651 (37.6) | 2650 (36.9) | 0.57 |
| Angiotensin receptor blocker use, n (%) | 603 (22.8) | 1382 (20.6) | 0.02 | 376 (21.7) | 1501 (20.9) | 0.45 |
| Systolic BP, mean±SD, mm Hg | 139.2±16.1 | 139.9±15.4 | 0.04 | 143.7±16.9 | 138.7±15.1 | <0.001 |
| Diastolic BP, mean±SD, mm Hg | 75.0±12.2 | 79.4±11.6 | <0.001 | 78.5±13.4 | 78.0±11.6 | 0.16 |
| Body mass index, mean±SD, kg/m2 | 29.4±5.8 | 30.0±5.8 | <0.001 | 29.7±6.1 | 29.9±5.7 | 0.28 |
| Medical Comorbidity Index ≥5, n (%)a | 1404 (53.2) | 2409 (36.0) | <0.001 | 861 (49.9) | 2795 (38.9) | <0.001 |
| Mental Comorbidity Index ≥2, n (%)a | 214 (8.1) | 682 (10.2) | 0.002 | 154 (8.9) | 702 (9.8) | 0.27 |
| eGFR, mean±SD, ml/min per 1.73 m2 | 47.9±9.5 | 81.2±15.5 | <0.001 | 63.1±22.8 | 74.5±18.8 | <0.001 |
| UACR, median (interquartile range), mg/g | 13.3 (6.4–43.1) | 8.6 (5.5–17.1) | <0.001 | 66.7 (42.1–162.1) | 7.7 (5.11–12.6) | <0.001 |
| Framingham 10-yr cardiovascular risk score, mean±SD, % | 27.1±14.3 | 23.9±11.7 | <0.001 | 28.6±14.2 | 24.1±12.0 | <0.001 |
| Montreal Cognitive Assessment, median (interquartile range)b | 23 (20–26) | 24 (21–26) | <0.001 | 23 (20–25) | 24 (21–26) | <0.001 |
P values on the basis of chi-square tests for categorical variables and t tests for continuous variables, with the exception of variables presented as median (interquartile range), which were tested with Wilcoxon rank sum tests. ACE, angiotensin-converting enzyme.
a
Scores on the Medical Comorbidity Index range from 0 to 30, with higher scores indicating more coexisting medical conditions. Scores on the Mental Comorbidity Index range from 0 to 6, with higher scores indicating more coexisting mental health conditions.
b
Scores for the Montreal Cognitive Assessment range from 0 to 30. Higher scores denote better cognitive function.