Table 4.
Effect of intensive BP target on cognitive impairment as a function of baseline eGFR and UACR
| Outcome | Intensive Treatment | Standard Treatment | Intensive versus Standard | Interaction P Value |
|---|---|---|---|---|
| No. of Cases/Cases per 1000 PY | No. of Cases/Cases per 1000 PY | HR (95% CI)a | ||
| eGFR, ml/min per 1.73 m2 | ||||
| Probable dementia | 0.95 | |||
| eGFR ≥60 | 81/5.4 | 100/6.7 | 0.81 (0.61 to 1.10) | |
| eGFR <60 | 68/12.0 | 76/14.1 | 0.79 (0.56 to 1.11) | |
| MCI | 0.04 | |||
| eGFR ≥60 | 170/11.8 | 244/17.1 | 0.71 (0.58 to 0.86) | |
| eGFR <60 | 117/22.1 | 109/21.7 | 1.00 (0.77 to 1.31) | |
| Probable dementia or MCI | 0.12 | |||
| eGFR ≥60 | 237/16.4 | 307/21.4 | 0.77 (0.65 to 0.92) | |
| eGFR <60 | 165/30.6 | 162/31.6 | 0.96 (0.77 to 1.20) | |
| UACR, mg/g | ||||
| Probable dementia | 0.27 | |||
| UACR <30 | 101/6.3 | 125/7.8 | 0.78 (0.60 to 1.02) | |
| UACR ≥30 | 44/12.3 | 43/12.5 | 1.08 (0.69 to 1.68) | |
| MCI | 0.43 | |||
| UACR <30 | 208/13.5 | 259/17.1 | 0.80 (0.67 to 0.96) | |
| UACR ≥30 | 72/21.5 | 74/23.1 | 0.89 (0.63 to 1.25) | |
| Probable dementia or MCI | 0.10 | |||
| UACR <30 | 283/18.2 | 342/22.5 | 0.82 (0.70 to 0.96) | |
| UACR ≥30 | 108/31.7 | 101/31.0 | 1.04 (0.78 to 1.38) |
PY person-years.
a
Intensive treatment group versus standard treatment group on the basis of Cox proportional hazards regression.